Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Can exercise ameliorate the increased risk of cardiovascular disease and diabetes associated with ADT?

Nature Clinical Practice Urology volume 5, pages 306–307 (2008)Cite this article

Androgen deprivation therapy (ADT) in the form of gonadotropin-releasing hormone (GnRH) agonists is being increasingly used in the management of prostate cancer, particularly as adjuvant treatment and for patients with early PSA relapse. ADT is, however, associated with a number of adverse effects, including reduced bone mass, increased risk of fracture at multiple sites, reduced lean mass and muscle strength, and increased fat mass: these effects compromise physical function, independence, and quality of life.1

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Galvão DA et al. (2007) Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer. Prostate Cancer Prostatic Dis 10: 340–346

    Article  Google Scholar 

  2. Keating NL et al. (2006) Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol 24: 4448–4456

    Article  CAS  Google Scholar 

  3. Saigal CS et al. (2007) Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancer. Cancer 110: 1493–1500

    Article  CAS  Google Scholar 

  4. D'Amico AV et al. (2007) Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarctions. J Clin Oncol 25: 2420–2425

    Article  CAS  Google Scholar 

  5. Tsai HK et al. (2007) Androgen deprivation therapy for localized prostate cancer and the risk of cardiovascular mortality. J Natl Cancer Inst 99: 1516–1524

    Article  Google Scholar 

  6. Helmrich SP et al. (1991) Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325: 147–152

    Article  CAS  Google Scholar 

  7. Trovati M et al. (1984) Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non-insulin-dependent diabetic patients. Diabetes Care 7: 416–420

    Article  CAS  Google Scholar 

  8. Wannamethee SG et al. (1998) Changes in physical activity, mortality, and incidence of coronary heart disease in older men. Lancet 351: 1603–1608

    Article  CAS  Google Scholar 

  9. Myers J et al. (2002) Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346: 793–801

    Article  Google Scholar 

  10. Galvão DA et al. (2006) Resistance training and reduction of treatment side effects in prostate cancer patients. Med Sci Sports Exerc 38: 2045–2052

    Article  Google Scholar 

Download references

Acknowledgements

We would like to acknowledge The Cancer Council of Western Australia and the Prostate Cancer Foundation of Australia.

Author information

Authors and Affiliations

  1. DA Galvão is a Research Fellow and RU Newton is the Professor of Exercise and Sports Science at the School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia,,

    Daniel A Galvão & Robert U Newton

  2. DR Taaffe is a Senior Lecturer at the School of Human Movement Studies, University of Queensland, Brisbane, Queensland, and,

    Dennis R Taaffe

  3. N Spry is a Clinical Associate Professor at the Department of Radiation Oncology, Sir Charles Gairdner Hospital and at the Faculty of Medicine, University of Western Australia, Nedlands, Western Australia, Australia.,

    Nigel Spry

Authors
  1. Daniel A Galvão
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert U Newton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dennis R Taaffe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nigel Spry
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert U Newton.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Galvão, D., Newton, R., Taaffe, D. et al. Can exercise ameliorate the increased risk of cardiovascular disease and diabetes associated with ADT?. Nat Rev Urol 5, 306–307 (2008). https://doi.org/10.1038/ncpuro1104

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpuro1104

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing