Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Anti-CD20 antibody is an efficient therapeutic tool for the selective removal of autoreactive T cells

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout


  1. Edwards JC and Cambridge G (2006) B-cell targeting in rheumatoid arthritis and other autoimmune diseases. Nat Rev Immunol 6: 394–403

    Article  CAS  Google Scholar 

  2. Cross AH et al. (2006) Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 180: 63–70

    Article  Google Scholar 

  3. Liossis S-NC and Sfikakis PP (2008) Rituximab-induced B cell depletion in autoimmune diseases: potential effects on T cells. Clin Immunol 127: 280–285

    Article  CAS  Google Scholar 

  4. Semple JW (2008) ITP three R's: regulation, routing and rituximab. Blood 112: 927–928

    Article  CAS  Google Scholar 

  5. Kaliyaperumal A et al. (1996) Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J Exp Med 183: 2459–2469

    Article  CAS  Google Scholar 

  6. Hu CY et al. (2007) Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest 117: 3857–3867

    Article  CAS  Google Scholar 

  7. Takemura S et al. (2001) T cell activation in rheumatoid synovium is B cell dependent. J Immunol 167: 4710–4718

    Article  CAS  Google Scholar 

  8. Serafini B et al. (2007) Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med 204: 2899–2912

    Article  CAS  Google Scholar 

  9. Kang H-K et al. (2005) Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets. J Immunol 174: 3247–3255

    Article  CAS  Google Scholar 

  10. Kang H-K et al. (2007) Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol 178: 7849–7858

    Article  CAS  Google Scholar 

  11. Hsieh C et al. (2008) In situ B cell mediated immune responses and tubulointerstitial inflammation in human lupus nephritis. Presented at the American College of Rheumatology Scientific Meeting: 2008 Oct 26–29, San Francisco, CA

  12. Mitchison NA (2004) T-cell-B-cell cooperation. Nat Rev Immunol 4: 308–312

    Article  CAS  Google Scholar 

  13. Rock KL et al. (1984) Antigen presentation by hapten-specific B lymphocytes. J Exp Med 160: 1102–1113

    Article  CAS  Google Scholar 

  14. Lanzavecchia A (1985) Antigen-specific interaction between T and B cells. Nature 314: 537–539

    Article  CAS  Google Scholar 

  15. Hamel K et al. (2008) Suppression of proteoglycan-induced arthritis by anti-CD20 B cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity. J Immunol 180: 4994–5003

    Article  CAS  Google Scholar 

  16. Taylor RP and Lindorfer MA (2007) Drug insight: the mechanism of action of rituximab in autoimmune disease—the immune complex decoy hypothesis. Nat Clin Pract Rheumatol 3: 86–95

    Article  CAS  Google Scholar 

  17. Uchida J et al. (2004) The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med 199: 1659–669

    Article  CAS  Google Scholar 

  18. Lefebvre ML et al. (2006) Ex vivo-activated human macrophages kill chronic lymphocytic leukemia cells in the presence of rituximab: mechanism of antibody-dependent cellular cytotoxicity and impact of human serum. J Immunother 29: 388–397

    Article  CAS  Google Scholar 

  19. Beum PV et al. (2008) Complement activation on B lymphocytes opsonized with rituximab or ofatumumab produces substantial changes in membrane structure preceding cell lysis. J Immunol 181: 822–832

    Article  CAS  Google Scholar 

  20. Cartron G et al. (2002) Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene. Blood 99: 754–758

    Article  CAS  Google Scholar 

  21. Garside P et al. (1998) Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281: 96–99

    Article  CAS  Google Scholar 

  22. Lehmann PV et al. (1992) Spreading of T cell autoimmunity to cryptic determinants of an autoantigen. Nature 358: 155–157

    Article  CAS  Google Scholar 

Download references


This work was supported by NIH grants R37–AR39157 and RO1–AI41985.

Author information

Authors and Affiliations


Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Datta, S. Anti-CD20 antibody is an efficient therapeutic tool for the selective removal of autoreactive T cells. Nat Rev Rheumatol 5, 80–82 (2009).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing