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Hypermobility: an important but often neglected area within rheumatology

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  1. Grahame R (2000) Pain, distress and joint hyperlaxity. Joint Bone Spine 67: 157–163

    CAS  PubMed  Google Scholar 

  2. Malfait F et al. (2006) The genetic basis of the joint hypermobility syndromes. Rheumatology (Oxford) 45: 502–507

    CAS  Article  Google Scholar 

  3. Grahame R (1999) Joint hypermobility and genetic collagen disorders: are they related? Arch Dis Child 80: 188–191

    CAS  Article  Google Scholar 

  4. Grahame R and Hakim AJ (2006) Joint hypermobility syndrome is highly prevalent in general rheumatology clinics, its occurrence and clinical presentation being gender, age and race-related [abstract]. Ann Rheum Dis 65 (Suppl 2): 263

    Google Scholar 

  5. Bravo JF and Wolff C (2006) Clinical study of hereditary disorders of connective tissues in a Chilean population: joint hypermobility syndrome and vascular Ehlers–Danlos syndrome. Arthritis Rheum 54: 515–523

    Article  Google Scholar 

  6. National Health Service Information Centre (online 16 April 2008) Hospital Outpatient Activity 2006–07 [] (accessed 7 August 2008)

  7. Royal College of Physicians (online 16 November 2004) Consultant workforce by specialty and country [] (accessed 8 August 2008)

  8. Grahame R and Bird H (2001) British consultant rheumatologists' perceptions about the hypermobility syndrome: a national survey. Rheumatology (Oxford) 40: 559–562

    CAS  Article  Google Scholar 

  9. Gawthorp F et al. (2007) Ehlers–Danlos syndrome. BMJ 335: 448–450

    Article  Google Scholar 

  10. Grahame R et al. (2000) The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol 27: 1777–1779

    CAS  PubMed  Google Scholar 

  11. Adib N et al. (2005) Joint hypermobility syndrome in childhood. A not so benign multisystem disorder? Rheumatology (Oxford) 44: 744–750

    CAS  Article  Google Scholar 

  12. Acasuso-Díaz M and Collantes-Estévez E (1998) Joint hypermobility in patients with fibromyalgia syndrome. Arthritis Care Res 11: 39–42

    Article  Google Scholar 

  13. Grahame R and Hakim AJ (2008) Hypermobility. Curr Opin Rheumatol 20: 106–110

    Article  Google Scholar 

  14. Gazit Y et al. (2003) Dysautonomia in the hypermobility syndrome. Am J Med 115: 33–40

    Article  Google Scholar 

  15. Reilly DJ et al. (2008) Connective tissue disorder—a new subgroup of boys with slow transit constipation. J Pediatr Surg 43: 1111–1114

    Article  Google Scholar 

  16. Ferrell WR et al. (2004) Amelioration of symptoms by enhancement of proprioception in patients with joint hypermobility syndrome. Arthritis Rheum 50: 3323–3328

    Article  Google Scholar 

  17. Kirby A and Davies R (2007) Developmental coordination disorder and joint hypermobility syndrome—overlapping disorders? Implications for research and clinical practice. Child Care Health Dev 32: 513–519

    Article  Google Scholar 

  18. Martín-Santos R et al. (1998) Association between joint hypermobility syndrome and panic disorder. Am J Psychiatry 155: 1578–1583

    Article  Google Scholar 

  19. Maillard SM et al. (2004) Physiotherapy management of benign joint hypermobility syndrome. Arthritis Rheum 50 (Suppl): S78

    Google Scholar 

  20. Keer G et al. (2003) Hypermobility Syndrome: Recognition and Management for Physiotherapists, edn 1. London: Butterworth–Heinemann

    Google Scholar 

  21. Simmonds JV and Keer RJ (2007) Hypermobility and the hypermobility syndrome. Man Ther 12: 298–309

    Article  Google Scholar 

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Grahame, R. Hypermobility: an important but often neglected area within rheumatology. Nat Rev Rheumatol 4, 522–524 (2008).

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