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Oral versus parenteral administration of methotrexate for the treatment of active RA

Nature Clinical Practice Rheumatology volume 4, pages 342343 (2008) | Download Citation

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  1. 1.

    and (2003) Low dose methotrexate and bone marrow suppression. BMJ 326: 266–267

  2. 2.

    et al. (1990) Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis. Arthritis Rheum 33: 91–94

  3. 3.

    et al. (1993) A comparison of low dose methotrexate bioavailability: oral solution, oral tablet, subcutaneous and intramuscular dosing. J Rheumatol 20: 1845–1849

  4. 4.

    et al. (2004) Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis. J Rheumatol 31: 645–648

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The synopsis was written by Lisa Richards, Editorial Assistant, Nature Clinical Practice.

Author information


  1. DJ Todd is a Rheumatology Fellow at the Brigham and Women's Hospital, and is affiliated with Harvard Medical School, Boston, MA, USA.

    • Derrick J Todd
  2. ME Weinblatt is Co-Director of Clinical Rheumatology at the Brigham and Women's Hospital and the John R and Eileen K Riedman Professor of Medicine at Harvard Medical School, Boston, MA, USA.

    • Michael E Weinblatt


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Competing interests

The authors declare no competing financial interests.

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Correspondence to Michael E Weinblatt.

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