Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Oral versus parenteral administration of methotrexate for the treatment of active RA

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Sosin M and Handa S (2003) Low dose methotrexate and bone marrow suppression. BMJ 326: 266–267

    Article  Google Scholar 

  2. Brooks PJ et al. (1990) Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis. Arthritis Rheum 33: 91–94

    Article  CAS  Google Scholar 

  3. Jundt JW et al. (1993) A comparison of low dose methotrexate bioavailability: oral solution, oral tablet, subcutaneous and intramuscular dosing. J Rheumatol 20: 1845–1849

    CAS  PubMed  Google Scholar 

  4. Hoekstra M et al. (2004) Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis. J Rheumatol 31: 645–648

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Lisa Richards, Editorial Assistant, Nature Clinical Practice.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael E Weinblatt.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Todd, D., Weinblatt, M. Oral versus parenteral administration of methotrexate for the treatment of active RA. Nat Rev Rheumatol 4, 342–343 (2008). https://doi.org/10.1038/ncprheum0827

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncprheum0827

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing