Abstract
Background A 32-year-old white man presented with features of inflammatory back pain, including awakening at night and morning stiffness. He had acute back pain 4 years earlier as a result of a herniated lumbar disc.
Investigations The orthopedic consultation included tests for neurologic deficits; a Lasègue test; a finger-to-floor distance test; X-rays of the lumbar spine; and MRI of the lumbar spine. The rheumatologic consultation included recordal of clinical history and family history; physical examination, including a Schober's test, lateral spine flexion, chest expansion, cervical rotation, and tragus-to-wall distance; blood tests, including genotyping for human leukocyte antigen B27 positivity, and measurements of C-reactive protein level and erythrocyte sedimentation rate; MRI of the sacroiliac joints with use of short tau inversion recovery sequences; and measurement of the Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index.
Diagnosis Axial undifferentiated spondyloarthritis.
Management NSAIDs and physiotherapy.
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References
Schober P (1937) Lendenwirbelsäule und Kreuzschmerzen [German]. Münch Med Wschr 84: 336–338
Jenkinson TR et al. (1994) Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS metrology index. J Rheumatol 21: 1694–1698
Van der Linden SM et al. (1984) Evaluation of the diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 27: 361–368
Rudwaleit M et al. (2005) The challenge of diagnosis and classification in early ankylosing spondylitis: do we need new criteria? Arthritis Rheum 52: 1000–1008
Rudwaleit M et al. (2004) How to diagnose axial spondyloarthritis early? Ann Rheum Dis 61: 535–543
Rudwaleit M et al. (2006) Easy assessment of axial spondyloarthritis (early ankylosing spondylitis) at the bedside. Ann Rheum Dis 65: 1251–1252
Calin A et al. (1977) Clinical history as a screening test for ankylosing spondylitis. JAMA 237: 2613–2614
Rudwaleit M et al. (2006) Inflammatory back pain in ankylosing spondylitis: a reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis Rheum 54: 569–578
Grimes DA and Schulz KF (2005) Refining clinical diagnosis with likelihood ratios. Lancet 365: 1500–1505
Muche B et al. (2003) Anatomic structures involved in early- and late-stage sacroiliitis in spondylarthritis: a detailed analysis by contrast-enhanced magnetic resonance imaging. Arthritis Rheum 48: 1374–1384
Oostveen J et al. (1999) Early detection of sacroiliitis on magnetic resonance imaging and subsequent development of sacroiliitis on plain radiography. A prospective, longitudinal study. J Rheumatol 26: 1953–1958
Amor B et al. (1995) Are classification criteria for spondylarthropathy useful as diagnostic criteria? Rev Rheum Engl Ed 62: 10–15
Wanders A et al. (2005) Nonsteroidal antiinflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: a randomized clinical trial. Arthritis Rheum 52: 1756–1765
Zochling J et al. (2006) ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 65: 442–452
Haibel H et al. (2007) No efficacy of subcutaneous methotrexate in active ankylosing spondylitis: a 16-week open-label trial. Ann Rheum Dis 66: 419–421
Braun J et al. (2005) Therapy of ankylosing spondylitis. Part II: biological therapies in the spondyloarthritides. Scand J Rheumatol 34: 178–190
Braun J et al. (2006) First update of the international ASAS consensus statement for the use of anti-TNF agents in patients with ankylosing spondylitis. Ann Rheum Dis 65: 316–320
Haibel H et al. (2006). Efficacy of adalimumab in the treatment of preradiographic axial spondyloarthritis—results of a 12 week randomized controlled trial [abstract]. Arthritis Rheum 54 (Suppl): L24
Rudwaleit M et al. (2004) Prediction of a major clinical response (BASDAI 50) to tumour necrosis factor alpha blockers in ankylosing spondylitis. Ann Rheum Dis 63: 665–670
Braun J et al. (2006) Major reduction in spinal inflammation in patients with ankylosing spondylitis after treatment with infliximab: results of a multicenter, randomized, double-blind, placebo-controlled magnetic resonance imaging study. Arthritis Rheum 54: 1646–1652
van der Heijde D et al. (2006) Two-year etanercept therapy does not inhibit radiographic progression in patients with ankylosing spondylitis [abstract]. Ann Rheum Dis 65 (Suppl 2): 81
Acknowledgements
We thank the German Ministry of Education and Research (BMBF) for financial support of our work in early spondyloarthritis, grant number FKZ 01GI9946.
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Rudwaleit, M., Sieper, J. A case of axial undifferentiated spondyloarthritis diagnosis and management. Nat Rev Rheumatol 3, 298–303 (2007). https://doi.org/10.1038/ncprheum0486
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DOI: https://doi.org/10.1038/ncprheum0486