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Mode of action of hydroxychloroquine in RA—evidence of an inhibitory effect on toll-like receptor signaling

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  1. Suarez-Almazor ME et al. (2000) Antimalarials for treating rheumatoid arthritis. Cochrane Database Syst Rev, Issue 4, Art. No CD000959

  2. O'Dell JR et al. (1996) Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications. N Engl J Med 334: 1287–1291

    CAS  Google Scholar 

  3. Rynes RI (1997) Antimalarial drugs in the treatment of rheumatological diseases. Br J Rheumatol 36: 799–805

    CAS  PubMed  Google Scholar 

  4. Weber SM and Levitz SM (2000) Chloroquine interferes with lipopolysaccharide-induced TNF-alpha gene expression by a nonlysosomotropic mechanism. J Immunol 165: 1534–1340

    CAS  PubMed  Google Scholar 

  5. Weber SM et al. (2002) Inhibition of mitogen-activated protein kinase signaling by chloroquine. J Immunol 168: 5303–5309

    CAS  PubMed  Google Scholar 

  6. Kim WU et al. (2006) Hydroxychloroquine potentiates Fas-mediated apoptosis of rheumatoid synoviocytes. Clin Exp Immunol 144: 503–511

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Leadbetter EA et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603–607

    CAS  PubMed  Google Scholar 

  8. Kyburz D and Gay S (2003) Toll-like receptors direct antimicrobial immune responses—and drive arthritis? Curr Rheumatol Rep 5: 407–408

    PubMed  Google Scholar 

  9. van der Heijden IM et al. (2000) Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis Rheum 43: 593–598

    CAS  PubMed  Google Scholar 

  10. Brentano F et al. (2005) RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum 52: 2656–2665

    CAS  PubMed  Google Scholar 

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Correspondence to Diego Kyburz.

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Kyburz, D., Brentano, F. & Gay, S. Mode of action of hydroxychloroquine in RA—evidence of an inhibitory effect on toll-like receptor signaling. Nat Rev Rheumatol 2, 458–459 (2006).

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