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Treatment of metastatic urachal carcinoma in an elderly woman

Nature Clinical Practice Oncology volume 5, pages 55–58 (2008)Cite this article

Abstract

Background A 67-year-old woman with a history of smoking presented with abdominal pain and hematuria. On physical examination, she had a palpable pelvic mass. Imaging revealed a large pelvic mass situated on the dome of the bladder, extending from the urachus, without evidence of other sites of metastases. After resection, urachal adenocarcinoma was histologically confirmed. No adjuvant therapy was administered. Repeat imaging obtained 3 months after resection revealed a large left pelvic mass consistent with recurrence.

Investigations Physical examination, pelvic and complete lymph-node examination, laboratory tests, urine analysis, CT scan of the abdomen and pelvis, chest X-ray, bone scan, cystoscopy, histologic examination of tumor morphology, and MRI of the abdomen and pelvis.

Diagnosis Metastatic urachal adenocarcinoma.

Management Surgical excision combined with cystectomy and pelvic lympadenectomy, chemotherapy with 5-fluorouracil, leucovorin, and irinotecan.

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Figure 1: Histological examination of the tumor.
Figure 2: Extent of disease before therapy.
Figure 3: Extent of disease after therapy.

References

  1. Wright JL et al. (2006) Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder. Cancer 107: 721–728

    Article  Google Scholar 

  2. Sheldon CA et al. (1984) Malignant urachal lesions. J Urol 131: 1–8

    Article  CAS  Google Scholar 

  3. Siefker-Radtke A (2006) Urachal carcinoma: surgical and chemotherapeutic options. Expert Rev Anticancer Ther 6: 1715–1721

    Article  CAS  Google Scholar 

  4. Ashley RA et al. (2006) Urachal carcinoma: clinicopathologic features and long-term outcomes of an aggressive malignancy. Cancer 107: 712–720

    Article  Google Scholar 

  5. Pinthus JH et al. (2006) Population based survival data on urachal tumors. J Urol 175: 2042–2047

    Article  Google Scholar 

  6. Siefker-Radtke A et al. (2003) Multimodality management of urachal carcinoma: the MD Anderson Cancer Center experience. J Urol 169: 1295–1298

    Article  Google Scholar 

  7. Herr HW et al. (1997) Urachal carcinoma: contemporary surgical outcomes. J Urol 178: 74–78

    Article  Google Scholar 

  8. Herr HW (1994) Urachal carcinoma: the case for extended partial cystectomy. J Urol 151: 365–366

    Article  CAS  Google Scholar 

  9. Kawakami S et al. (2001) Successful treatment of metastatic adenocarcinoma of the urachus: report of 2 cases with more than 10-year survival. Urology 58: 462

    Article  CAS  Google Scholar 

  10. Logothetis CJ et al. (1985) Chemotherapy for adenocarcinomas of bladder and urachal origin: 5-fluorouracil, doxorubicin, and mitomycin-C. Urology 26: 252–255

    Article  CAS  Google Scholar 

  11. Ichiyanagi O et al. (1998) Successful chemotherapy in a patient with recurrent carcinoma of the urachus. Int Urol Nephrol 30: 569–573

    Article  CAS  Google Scholar 

  12. Quilty PM (1987) Urachal carcinoma: a response to chemotherapy. Br J Urol 60: 372

    Article  CAS  Google Scholar 

  13. Rothenberg ML et al. (1993) Phase I and pharmacokinetic trial of weekly CPT-11. J Clin Oncol 11: 2194–2204

    Article  CAS  Google Scholar 

  14. Hurwitz HI et al. (2005) Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer. J Clin Oncol 23: 3502–3508

    Article  CAS  Google Scholar 

  15. Pozzo C et al. (2004) Irinotecan in combination with 5-fluorouracil and folinic acid or with cisplatin in patients with advanced gastric or esophageal-gastric junction adenocarcinoma: results of a randomized phase II study. Ann Oncol 15: 1773–1781

    Article  CAS  Google Scholar 

  16. Bouche O et al. (2004) Randomized multicenter phase II trial of a biweekly regimen of fluorouracil and leucovorin (LV5FU2), LV5FU2 plus cisplatin, or LV5FU2 plus irinotecan in patients with previously untreated metastatic gastric cancer: a Federation Francophone de Cancerologie Digestive Group Study—FFCD 9803. J Clin Oncol 22: 4319–4328

    Article  CAS  Google Scholar 

  17. Kume H et al. (2006) Irinotecan as a new agent for urachal cancer. Urol Int 76: 281–282

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. SG Mohile is an Assistant Professor of Medicine at the University of Rochester, Rochester,

    Supriya G Mohile

  2. L Schleicher is a Hematology/Oncology Fellow and DP Petrylak is an Associate Professor of Medicine both at the Columbia University Medical Center, New York, NY, USA.,

    Lori Schleicher & Daniel P Petrylak

Authors
  1. Supriya G Mohile
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  2. Lori Schleicher
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  3. Daniel P Petrylak
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Corresponding author

Correspondence to Supriya G Mohile.

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The authors declare no competing financial interests.

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Mohile, S., Schleicher, L. & Petrylak, D. Treatment of metastatic urachal carcinoma in an elderly woman. Nat Rev Clin Oncol 5, 55–58 (2008). https://doi.org/10.1038/ncponc1009

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