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References
Coates AS et al. (2007) Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98. J Clin Oncol 25: 486–492
Buzdar AU and Cuzick J (2006) Anastrozole as an adjuvant endocrine treatment for postmenopausal patients with breast cancer: emerging data. Clin Cancer Res 12 (Suppl): S1037–S1048
Jin Y et al. (2005) CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 97: 30–39
Goetz MP et al. (2005) Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 23: 9312–9318
Goetz MP et al. (2007) The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 101: 113–121
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The synopsis was written by Helen Jaques, Editorial Assistant, Nature Clinical Practice.
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Dr Goetz is a co-inventor on a pending patent application that is owned by the Mayo Foundation for Medical Education and Research and is related to the use of CYP2D6 as a predictor of recurrence in tamoxifen-treated breast cancer. Dr Goetz reports that he is a consultant to Roche and DNA Direct.
CL Loprinzi declared no competing interests.
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Goetz, M., Loprinzi, C. Aromatase inhibitors and tamoxifen: where do we go from here?. Nat Rev Clin Oncol 4, 626–627 (2007). https://doi.org/10.1038/ncponc0955
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DOI: https://doi.org/10.1038/ncponc0955