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The Norton–Simon hypothesis: designing more effective and less toxic chemotherapeutic regimens

Nature Clinical Practice Oncology volume 3, pages 406–407 (2006)Cite this article

Successful treatment of bacterial infections is largely a result of our ability to exploit the biochemical differences between bacteria and human cells so as to achieve toxic drug concentrations in the former while sparing the latter. Unfortunately, such high selectivity is at present elusive in the chemotherapy of human cancers. Hence, great effort is required to determine dose schedules that maximize the benefit/toxicity ratio, particularly for multiple agent regimens.

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Authors and Affiliations

  1. Chief of the Biometric Research Branch at the National Cancer Institute, Bethesda, MD, USA

    Richard Simon

  2. Memorial Hospital,

    Larry Norton

  3. Evelyn H. Lauder Breast Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Larry Norton

Authors
  1. Richard Simon
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  2. Larry Norton
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Correspondence to Richard Simon.

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The authors declare no competing financial interests.

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Simon, R., Norton, L. The Norton–Simon hypothesis: designing more effective and less toxic chemotherapeutic regimens. Nat Rev Clin Oncol 3, 406–407 (2006). https://doi.org/10.1038/ncponc0560

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  • DOI: https://doi.org/10.1038/ncponc0560

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