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Is pathologic complete remission a useful measure of response to novel therapies in neoadjuvant trials?

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References

  1. Wolmark N et al. (2001) Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18. J Natl Cancer Inst Monogr 30: 96–102

    Article  Google Scholar 

  2. Bear HD et al. (2004) A randomized trial comparing preoperative doxorubicin/cyclophosphamide (AC) to preoperative AC followed by preoperative docetaxel (T) and to preoperative AC followed by postoperative T in patients with operable carcinoma of the breast: results of NSABP B-27. Breast Cancer Res Treat 88 (Suppl 1): aS26

    Google Scholar 

  3. Ring AE et al. (2004) Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer. Br J Cancer 91: 2012–2017

    Article  Google Scholar 

  4. Seidman AD et al. (2004) CALGB 9840: phase III study of weekly (W) paclitaxel (P) via 1-hour (h) infusion versus standard (S) 3h infusion every third week in the treatment of metastatic breast cancer (MBC), with trastuzumab (T) for HER2 positive MBC and randomized for T in HER2 normal MBC. J Clin Oncol 22 (Suppl 14): aS512

    Article  Google Scholar 

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Acknowledgements

The synopsis was written by Petra Roberts, Associate Editor, Nature Clinical Practice.

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Correspondence to Ian Smith.

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Leary, A., Smith, I. Is pathologic complete remission a useful measure of response to novel therapies in neoadjuvant trials?. Nat Rev Clin Oncol 3, 126–127 (2006). https://doi.org/10.1038/ncponc0447

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