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Palpable right breast mass in a pregnant woman

Nature Clinical Practice Oncology volume 2, pages 218–221 (2005)Cite this article

Abstract

Background A 29-year-old female presented with a palpable right breast mass at a 12-week prenatal visit. She had no family history of breast or ovarian cancer. Ultrasound revealed a 3 cm lobulated mass, which was confirmed to be malignant by a core biopsy. Postmastectomy pathology at 15 weeks' gestation demonstrated this mass to be a stage T2N0M0 high-grade invasive ductal carcinoma with 0/20 axillary nodes involved. A staging CT scan postpartum showed an enlarged right internal mammary lymph node, confirmed by MRI as suspicious for malignancy.

Investigations Physical examination, breast ultrasound, core biopsy, mastectomy, CT scan, MRI.

Diagnosis Pregnancy-associated breast carcinoma.

Management Mastectomy, chemotherapy and radiotherapy.

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Figure 1: Postpartum contrast-enhanced helical chest CT scan showing an enlarged internal mammary lymph node (white arrow).
Figure 2: Breast MRI with ultrasmall superparamagnetic iron oxide demonstrates both the enlarged right internal mammary node (white arrow) and right chest wall lesion (black arrow) with hyperintensity, indicating a tumor.

References

  1. Greene FL et al. (Eds; 2002) AJCC Cancer Staging Manual, edn 6. New York: Springer

    Book  Google Scholar 

  2. Lowe SA (2004) Diagnostic radiography in pregnancy: risks and reality. Aust N Z J Obstet Gynaecol 44: 191–196

    Article  Google Scholar 

  3. De Wilde JP et al. (2005) A review of the current use of magnetic resonance imaging in pregnancy and safety implications for the fetus. Prog Biophys Mol Biol 87: 335–353

    CAS  Article  Google Scholar 

  4. Schelfout K et al. (2004) Contrast-enhanced MR imaging of breast lesions and effect on treatment. Eur J Surg Oncol 30: 501–507

    CAS  Article  Google Scholar 

  5. Harisinghani MG et al. (2003) Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 348: 2491–2499

    Article  Google Scholar 

  6. Eifel P et al. (2001) National Institutes of Health Consensus Development Conference Statement: adjuvant therapy for breast cancer, November 1–3, 2000. J Natl Cancer Inst 93: 979–989

    CAS  Article  Google Scholar 

  7. Shousha S (2000) Breast carcinoma presenting during or shortly after pregnancy and lactation. Arch Pathol Lab Med 124: 1053–1060

    CAS  PubMed  Google Scholar 

  8. Burstein HJ et al. (2002) Treatment of breast cancer during pregnancy. Expert Opin Pharmacother 3: 423–428

    Article  Google Scholar 

  9. Recht A et al. (1996) The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. N Engl J Med 334: 1356–1361

    CAS  Article  Google Scholar 

  10. Recht A et al. (1999) Locoregional failure 10 years after mastectomy and adjuvant chemotherapy with or without tamoxifen without irradiation: experience of the Eastern Cooperative Oncology Group. J Clin Oncol 17: 1689–1700

    CAS  Article  Google Scholar 

  11. Overgaard M et al. (1997) Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 337: 949–955

    CAS  Article  Google Scholar 

  12. Ragaz J et al. (1997) Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 337: 956–962

    CAS  Article  Google Scholar 

  13. Poortmans P et al. (2003) Quality assurance of EORTC trial 22922/10925 investigating the role of internal mammary—medial supraclavicular irradiation in stage I-III breast cancer: the individual case review. Eur J Cancer 39: 2035–2042

    CAS  Article  Google Scholar 

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Authors and Affiliations

  1. Massachusetts General Hospital,

    Matthew S Katz, Lidia Schapira, Mukesh G Harisinghani & Kevin S Hughes

  2. Harvard Medical School,

    Matthew S Katz, Lidia Schapira, Mukesh G Harisinghani & Kevin S Hughes

  3. Massachusetts General Hospital,

    Matthew S Katz, Lidia Schapira, Mukesh G Harisinghani & Kevin S Hughes

  4. Harvard Medical School,

    Matthew S Katz, Lidia Schapira, Mukesh G Harisinghani & Kevin S Hughes

  5. Massachusetts General Hospital,

    Matthew S Katz, Lidia Schapira, Mukesh G Harisinghani & Kevin S Hughes

  6. Harvard Medical School,

    Matthew S Katz, Lidia Schapira, Mukesh G Harisinghani & Kevin S Hughes

  7. Avon Foundation Comprehensive Breast Evaluation Center and the Breast and Ovarian Cancer Genetics and Risk Assessment Program at Massachusetts General Hospital,

    Matthew S Katz, Lidia Schapira, Mukesh G Harisinghani & Kevin S Hughes

  8. Harvard Medical School, Boston, MA, USA

    Matthew S Katz, Lidia Schapira, Mukesh G Harisinghani & Kevin S Hughes

Authors
  1. Matthew S Katz
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  2. Lidia Schapira
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  3. Mukesh G Harisinghani
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  4. Kevin S Hughes
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Corresponding author

Correspondence to Matthew S Katz.

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Competing interests

The authors declare no competing financial interests.

Glossary

ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE (USPIO)

MRI contrast used to detect functional, rather than architectural, changes to identify nodal metastases from solid tumors

ACT

Doxorubicin, cyclophosphamide and paclitaxel

IPSILATERAL SUPRACLAVICULAR FOSSA

Regional lymph nodes on the same side of the body as the tumor that are a potential site of nodal drainage from the internal mammary or axillary lymph nodes

AJCC STAGING SYSTEM

A clinical and pathological staging system established by the American Joint Committee on Cancer to reflect prognostic factors for survival in most solid tumors, including breast cancer

SENTINEL LYMPH-NODE MAPPING

Minimally invasive surgery to assess lymph nodes most likely to be affected by the spread of a primary solid tumor

EORTC

European Organization for Research and Treatment of Cancer

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Katz, M., Schapira, L., Harisinghani, M. et al. Palpable right breast mass in a pregnant woman. Nat Rev Clin Oncol 2, 218–221 (2005). https://doi.org/10.1038/ncponc0135

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  • DOI: https://doi.org/10.1038/ncponc0135

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