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Should all patients at high risk of atherothrombotic events receive dual antiplatelet therapy?

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References

  1. Diener HC et al. (2004) Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364: 331–337

    Article  CAS  Google Scholar 

  2. CAPRIE Steering Committee (1996) A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348: 1329–1339

  3. The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators (2001) Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345: 494–502

  4. Sabatine MS et al. (2005) Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 352: 1179–1189

    Article  CAS  Google Scholar 

  5. Smith SC Jr et al. (2006) AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute. Circulation 113: 2363–2372

    Article  Google Scholar 

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Acknowledgements

The synopsis was written by Hannah Camm, Editor, Nature Clinical Practice.

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Correspondence to Robert J Adams.

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Robert Adams has given lectures sponsored by Boehringer Ingelheim, Bristol-Myers Squibb, Novartis and Sanofi-Aventis. He is on advisory committees in the area of stroke for Boehringer Ingelheim, Bristol-Myers Squibb and Sanofi-Aventis.

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Adams, R. Should all patients at high risk of atherothrombotic events receive dual antiplatelet therapy?. Nat Rev Neurol 2, 532–533 (2006). https://doi.org/10.1038/ncpneuro0297

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