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Levodopa—toxic or neuroprotective?

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  1. Cotzias GC et al. (1967) Aromatic amino acids and modification of parkinsonism. N Engl J Med 276: 374–379

    Article  CAS  Google Scholar 

  2. Fahn S (1996) Is levodopa toxic? Neurology 47 (Suppl 3): S184–S195

    Article  CAS  Google Scholar 

  3. Agid Y (1998) Levodopa: is toxicity a myth? Neurology 50: 858–863

    Article  CAS  Google Scholar 

  4. Weiner WJ (2004) Initial treatment of Parkinson's disease: levodopa or dopamine agonists. Arch Neurol 61: 1966–1969

    PubMed  Google Scholar 

  5. Ahlskog JE (2003) Slowing Parkinson's disease progression: recent dopamine agonist trials. Neurology 60: 381–389

    Article  Google Scholar 

  6. Hely MA et al. (2005) Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord 20: 190–199

    Article  Google Scholar 

  7. Fahn S et al. (2004) Levodopa and the progression of Parkinson's disease. N Engl J Med 351: 2498–2508

    Article  CAS  Google Scholar 

  8. Rajput AH et al. (1997) Is levodopa toxic to human substantia nigra? Mov Disord 12: 634–638

    Article  CAS  Google Scholar 

  9. Quinn N et al. (1986) Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period. Mov Disord 1: 65–68

    Article  CAS  Google Scholar 

  10. Yahr MD et al. (1972) Autopsy findings in parkinsonism following treatment with levodopa. Neurology 22 (Suppl): 56–71

    Article  Google Scholar 

  11. Miyasaki JM et al. (2002) Practice parameter: initiation of treatment for Parkinson's disease: an evidence-based review. Neurology 58: 11–17

    Article  CAS  Google Scholar 

Download references

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Correspondence to William J Weiner.

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Weiner, W. Levodopa—toxic or neuroprotective?. Nat Rev Neurol 2, 518–519 (2006).

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