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A case of fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion

Nature Clinical Practice Nephrology volume 4, pages 278–282 (2008)Cite this article

Abstract

Background A 58-year-old schizophrenic male who had been drinking at least 4–5 l of pure water every day for 30 years was admitted to a hospital with complaints of nausea, fatigue, and irregular, fluctuating fevers (up to 39 °C). He had previously been prescribed fluoxetine at a dose of 20 mg/day and had been using the drug for 28 days.

Investigations Review of medical history, physical examination, blood analysis, urine analysis, chest radiography and abdominal ultrasound.

Diagnosis Psychogenic polydipsia and fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion.

Management Fluid restriction and discontinuation of fluoxetine.

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Figure 1: Changes in the patient's serum sodium level during follow-up by the nephrology unit.

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Authors and Affiliations

  1. EB Ozsenel is a Senior Resident in the Department of Internal Medicine, and R Kazancioglu is an Associate Professor of Nephrology and Head of the Department of Nephrology, S Ozturk is a Nephrologist, all at the Haseki Training and Research Hospital, and A Turkmen is a Professor of Nephrology in the Faculty of Medicine at Istanbul University, Istanbul, Turkey.,

    Savas Ozturk, Ekmel Burak Ozsenel, Rumeyza Kazancioglu & Aydin Turkmen

Authors
  1. Savas Ozturk
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  2. Ekmel Burak Ozsenel
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  3. Rumeyza Kazancioglu
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  4. Aydin Turkmen
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Correspondence to Savas Ozturk.

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The authors declare no competing financial interests.

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Ozturk, S., Ozsenel, E., Kazancioglu, R. et al. A case of fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion. Nat Rev Nephrol 4, 278–282 (2008). https://doi.org/10.1038/ncpneph0780

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