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Idiopathic hypocomplementemic immune-complex-mediated tubulointerstitial nephritis

Nature Clinical Practice Nephrology volume 3, pages 50–58 (2007)Cite this article

Abstract

Background A 42-year-old man presenting with flank pain was found to have renal failure with severe hypocomplementemia and eosinophilia.

Investigations Physical examination, laboratory testing, renal ultrasonography, and renal biopsies.

Diagnosis Acute immune-complex-mediated tubulointerstitial nephritis.

Management Immunosuppressive therapy with 1 mg/kg/day prednisone.

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Figure 1: Histology of the patient's first renal biopsy (hematoxylin and eosin, ×200).
Figure 2: Fluorescence microscopy of the patient's first renal biopsy (rabbit anti-human IgG, ×200).
Figure 3: Electron microscopy of the patient's first renal biopsy (uranyl acetate and lead citrate, ×2,500).
Figure 4: Histology of the patient's second renal biopsy (hematoxylin and eosin, ×200).

References

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Authors and Affiliations

  1. M Vaseemuddin is Chief Resident at John H Stroger Jr Hospital of Cook County. MM Schwartz is Professor of Pathology at Rush University. G Dunea is Chairman of the Division of Nephrology at John H Stroger Jr Hospital of Cook County and Professor of Medicine at the University of Illinois. MA Kraus is an Attending Nephrologist at John H Stroger Jr Hospital of Cook County, Chicago, IL, USA.,

    Mohammad Vaseemuddin, Melvin M Schwartz, George Dunea & Mark A Kraus

Authors
  1. Mohammad Vaseemuddin
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  2. Melvin M Schwartz
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  3. George Dunea
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  4. Mark A Kraus
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Corresponding author

Correspondence to Mark A Kraus.

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Competing interests

The authors declare no competing financial interests.

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Cite this article

Vaseemuddin, M., Schwartz, M., Dunea, G. et al. Idiopathic hypocomplementemic immune-complex-mediated tubulointerstitial nephritis. Nat Rev Nephrol 3, 50–58 (2007). https://doi.org/10.1038/ncpneph0347

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  • DOI: https://doi.org/10.1038/ncpneph0347

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