Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

What are the risk factors for surgery and their implications for management of children with Crohn's disease?

Nature Clinical Practice Gastroenterology & Hepatology volume 3, pages 660–661 (2006)Cite this article

boxed-textGupta N et al. (2006) Risk factors for initial surgery in pediatric patients with Crohn's disease. Gastroenterology 130: 1069–1077

Aggressive medical therapy in pediatric-onset Crohn's disease might be considered to decrease the need for surgery in children with additional surgical risk factors (female sex, growth failure, and complicated disease)

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Mekhjian H et al. (1979) National Cooperative Crohn's Disease Study: factors determining recurrence of Crohn's disease after surgery. Gastroenterology 77: 907–913

    CAS  PubMed  Google Scholar 

  2. Kugathasan S et al. (2004) CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease. Clin Gastroenterol Hepatol 11: 1003–1009

    Article  Google Scholar 

  3. Baldassano RN et al. (2001) Pediatric Crohn's disease: risk factors for postoperative recurrence. Am J Gastroenterol 96: 2169–2176

    Article  CAS  Google Scholar 

  4. Sands BE et al. (2003) Risk of early surgery for Crohn's disease: implications for early treatment strategies. Am J Gastroenterol 98: 2712–2718

    Article  Google Scholar 

  5. Dubinsky MC et al. (2006) Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression. Am J Gastroenterol 101: 360–367

    Article  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor Nature Clinical Practice.

Author information

Authors and Affiliations

  1. Pediatric Gastroenterology Fellow Medical College of Wisconsin, Milwaukee, WI, USA

    Vincent F Biank

  2. Associate Professor in Pediatrics at the Medical College of Wisconsin, Milwaukee, WI, USA

    Subra Kugathasan

Authors
  1. Vincent F Biank
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Subra Kugathasan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Subra Kugathasan.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Biank, V., Kugathasan, S. What are the risk factors for surgery and their implications for management of children with Crohn's disease?. Nat Rev Gastroenterol Hepatol 3, 660–661 (2006). https://doi.org/10.1038/ncpgasthep0658

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpgasthep0658

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing