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Hepatic adenomatosis in a young woman with glucose intolerance

Abstract

Background A 30-year-old white woman presented to our department in December 2004 for clinical evaluation of episodic, severe, right upper quadrant pain. She was otherwise healthy and her only medication was a daily oral contraceptive pill. Her past medical history was notable for gestational diabetes and fasting hyperglycemia since her pregnancy. Family history was significant for a younger sister with diabetes mellitus, but no known family history of liver disease.

Investigations Physical examination, laboratory investigations, multiphasic CT scan of the abdomen, exploratory laparotomy with biopsies.

Diagnosis Hepatic adenomatosis.

Management Subsegmental hepatic resection followed by interval, long-term follow-up with hepatic imaging.

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Figure 1: CT scan of the liver of a 30-year-old woman who presented with right upper quadrant pain.
Figure 2: Gross surgical liver specimen of a 30-year-old woman presenting with right upper quadrant pain.
Figure 3: Subsegmental resection histologic specimen of one adenoma in a 30-year-old woman with hepatic adenomatosis (hematoxylin and eosin stain, original magnification × 100).
Figure 4: Proposed algorithm for management of patients with hepatic adenomatosis.

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Correspondence to Gregory J Gores.

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Bambha, K., Nagorney, D., Sanderson, S. et al. Hepatic adenomatosis in a young woman with glucose intolerance. Nat Rev Gastroenterol Hepatol 3, 526–531 (2006). https://doi.org/10.1038/ncpgasthep0576

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  • DOI: https://doi.org/10.1038/ncpgasthep0576

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