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Molecular screening for Lynch syndrome

Nature Clinical Practice Gastroenterology & Hepatology volume 2, pages 392–393 (2005)Cite this article

boxed-textHampel H et al. (2005) Screening for the Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer). N Engl J Med 352: 1851–1860

Patients with Lynch syndrome can be detected by screening colorectal cancers for microsatellite instability or using immunohistochemistry, both of which are equally sensitive and effective

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References

  1. Lynch HT and de la Chapelle A (2003) Hereditary colorectal cancer. N Engl J Med 348: 919–932

    Article  CAS  Google Scholar 

  2. Truninger K et al. (2005) Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. Gastroenterology 128: 1160–1171

    Article  CAS  Google Scholar 

  3. Umar A et al. (2004) Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96: 261–268

    Article  CAS  Google Scholar 

  4. Lindor NM et al. (2005) Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA 293: 1979–1985

    Article  CAS  Google Scholar 

  5. Casey G et al. (2005) Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer. JAMA 293: 799–809

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Rachel Jones, Associate Editor, Nature Clinical Practice.

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  1. Chief of Gastroenterology at Baylor University Medical Center, Dallas, TX, USA

    C Richard Boland

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  1. C Richard Boland
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Correspondence to C Richard Boland.

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The author declares no competing financial interests.

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Boland, C. Molecular screening for Lynch syndrome. Nat Rev Gastroenterol Hepatol 2, 392–393 (2005). https://doi.org/10.1038/ncpgasthep0263

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  • DOI: https://doi.org/10.1038/ncpgasthep0263

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