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How effective is continuous glucose monitoring in intensively treated type 1 diabetes mellitus?


This Practice Point commentary discusses the findings of a multicenter clinical trial conducted by the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. In the study, 322 individuals aged ≥8 years who were already receiving intensive insulin therapy for type 1 diabetes mellitus were randomly assigned to either a group that performed continuous glucose monitoring (CGM), or to a control group that performed conventional self-monitoring with a blood-glucose meter. At week 26, the between-group difference in the change in HbA1c level from baseline varied according to the patient's age. A significantly greater reduction in HbA1c level in the CGM group compared with the control group was found in patients aged ≥25 years, but not in those aged 8–14 years or 15–24 years. In patients aged ≥25 years, CGM improved glycemic control without increasing the frequency of hypoglycemia. Motivation, willingness to change diabetes self-care behaviors, and the ability to use CGM effectively are important determinants of whether this technology will improve glycemic control.

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  1. Kovatchev B et al. (2008) Comparison of the numerical and clinical accuracy of four continuous glucose monitors. Diabetes Care 31: 1160–1164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Buckingham B (2008) Clinical overview of continuous glucose monitoring. J Diabetes Sci Technol 2: 300–306

    Article  PubMed  PubMed Central  Google Scholar 

  3. Garg S et al. (2006) Improvement in glycemic excursions with a transcutaneous, real-time continuous glucose sensor: a randomized controlled trial. Diabetes Care 29: 44–50

    Article  CAS  PubMed  Google Scholar 

  4. Deiss D et al. (2006) Improved glycemic control in poorly controlled patients with type 1 diabetes using real-time continuous glucose monitoring. Diabetes Care 29: 2730–2732

    Article  PubMed  Google Scholar 

  5. Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group et al. (2008) Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med 359: 1464–1476

  6. Petitti DB et al. (2007) Serum lipids and glucose control: the SEARCH for Diabetes in Youth study. Arch Pediatr Adolesc Med 161: 159–165

    Article  PubMed  Google Scholar 

  7. Nathan DM et al. (2005) Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353: 2643–2653

    Article  Google Scholar 

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Wolfsdorf, J. How effective is continuous glucose monitoring in intensively treated type 1 diabetes mellitus?. Nat Rev Endocrinol 5, 134–135 (2009).

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