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Mineralocorticoid-receptor blockade, hypertension and heart failure

Nature Clinical Practice Endocrinology & Metabolism volume 1, pages 4–5 (2005)Cite this article

Should mineralocorticoid-receptor (MR) antagonists be used in hypertension and heart failure? In the beginning, the answer is yes. As outlined below, the mechanisms involved are still unclear, and the present focus on aldosterone rather than MRs largely misplaced. But the data are in and the message is clear, from laboratory studies and clinical trials, in particular RALES,1 EPHESUS2 and the 4E trial.3

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Authors and Affiliations

  1. Professor of Medicine at Monash University, a Senior Fellow at Prince Henry's Institute, Monash Medical Centre, Melbourne, and a Professorial Associate of the Centre for Neuroscience, University of Melbourne, Australia

    John W Funder

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  1. John W Funder
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Correspondence to John W Funder.

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Competing interests

Dr Funder is a consultant for Eli Lilly, Merck, Pfizer, cBio, Exelisis, GNF and Kalypsis, and holds research grants from Merck and Pfizer.

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Funder, J. Mineralocorticoid-receptor blockade, hypertension and heart failure. Nat Rev Endocrinol 1, 4–5 (2005). https://doi.org/10.1038/ncpendmet0016

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