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Future investigations in stem cell activation with granulocyte-colony-stimulating factor after myocardial infarction

Nature Clinical Practice Cardiovascular Medicine volume 4, pages S119–S122 (2007)Cite this article

Abstract

Experimental data indicate that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) might have potential as a novel therapeutic strategy for acute myocardial infarction. The prospective beneficial effects of G-CSF can be attributed mainly to a direct action on injured myocardium rather than on differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews the evidence for the potential cardioprotective effects of G-CSF and discusses future investigations regarding pharmacologic stem cell activation and mobilization with G-CSF in the setting of acute myocardial infarction.

Key Points

  • Experimental data indicate that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) has potential as a novel regenerative strategy after acute myocardial infarction

  • The prospective beneficial effects of G-CSF can be attributed mainly to a direct action on injured myocardium rather than on differentiation of mobilized bone marrow stem cells into cardiac myocytes

  • Antiapoptotic and angiogenic effects of G-CSF could conceivably have an impact on left ventricular remodeling after acute myocardial infarction

  • With regards to future treatment strategies for acute myocardial infarction, further experimental and clinical studies are needed to identify effective and safe ways to use G-CSF

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Authors and Affiliations

  1. H Ince is an interventional cardiologist in the Department of Medicine and CA Niénábér is Medical Director of the Cardiology Department in the Department of Medicine, Division of Cardiology, at the University Hospital Rostock, Rostock School of Medicine, Germany.,

    Hüseyin Ince & Christoph A Nienaber

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  1. Hüseyin Ince
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  2. Christoph A Nienaber
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Correspondence to Hüseyin Ince.

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The authors declare no competing financial interests.

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Ince, H., Nienaber, C. Future investigations in stem cell activation with granulocyte-colony-stimulating factor after myocardial infarction. Nat Rev Cardiol 4 (Suppl 1), S119–S122 (2007). https://doi.org/10.1038/ncpcardio0732

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  • DOI: https://doi.org/10.1038/ncpcardio0732

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