Abstract
Background A 47-year-old woman with obstructive hypertrophic cardiomyopathy presented with chest pain that had persisted despite treatment with verapamil and α-receptor antagonists. The patient had no other significant cardiac symptoms, no history of hypertension, and no familial predisposition to hypertrophic cardiomyopathy or sudden cardiac death. A loud (grade III/VI), dynamic, systolic ejection murmur was noted that could be heard diffusely over the precordium.
Investigations Radionuclide perfusion imaging, coronary angiography, intracoronary Doppler flow measurements, and ambulatory electrocardiographic monitoring.
Diagnosis Obstructive hypertrophic cardiomyopathy, myocardial ischemia and sudden cardiac arrest.
Management Surgical myectomy and cardioverter-defibrillator implantation.
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Vaglio, J., Sorajja, P. & Gersh, B. Ambulatory monitoring of aborted sudden cardiac death related to hypertrophic cardiomyopathy. Nat Rev Cardiol 2, 659–662 (2005). https://doi.org/10.1038/ncpcardio0381
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DOI: https://doi.org/10.1038/ncpcardio0381
