Intracardiac leiomyomatosis: iliac vein to right-ventricular outflow tract

Article metrics


Background A 58-year-old female with a history of hypertension and asthma presented to an internist for a routine physical examination. A grade II/VI systolic ejection murmur and electrocardiogram abnormalities were noted. She was referred to a cardiologist for further assessment.

Investigations Transthoracic echocardiography, transesophageal echocardiography, contrast-enhanced CT and MRI, exploratory laparotomy.

Diagnosis Intracardiac leiomyomatosis.

Management Surgical excision.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Transesophageal echocardiogram.
Figure 2: Gross pathologic specimen of leiomyoma measuring 30.0 cm in length, with a diameter ranging from 1.5 to 2.5 cm.
Figure 3: Microscopic examination of leiomyoma with focal hyalinization and myxoid degeneration.


  1. 1

    Gopal AS et al. (2001) Differential diagnosis of intracavitary tumors obstructing the right ventricular outflow tract. J Am Soc Echocardiogr 14: 937–940

  2. 2

    Goldman A et al. (1985) Renal cell carcinoma and right atrial tumor diagnosed by echocardiography. Am Heart J 110 (Pt 1): 183–186

  3. 3

    Farooki ZQ et al. (1975) Echocardiographic diagnosis of right atrial extension of Wilms' tumor. Am J Cardiol 36: 363–365

  4. 4

    Gonzalez-Lavin L et al. (1984) Tricuspid valve obstruction due to intravenous leiomyomatosis. Am Heart J 108: 1544–1546

  5. 5

    Hayasaka K et al. (2000) Intravenous leiomyomatosis. J Comput Assist Tomogr 24: 83–85

  6. 6

    Lam PM et al. (2004) Intravenous leimyomatosis: two cases with different routes of tumor extension. J Vasc Surg 39: 465–469

  7. 7

    Steinmetz OK et al. (1996) Uterine tumor in the heart: intravenous leiomyomatosis. Surgery 119: 226–229

  8. 8

    Matsumoto K et al. (1994) Intravenous leiomyomatosis of the uterus. Eur J Vasc Surg 8: 377–378

  9. 9

    Bahary CM et al. (1982) Intravascular leiomyomatosis. Obstet Gyncol 59 (Suppl): 73S–77S

  10. 10

    Roques F et al. (2001) Role of pre-operative assessment in the surgical management of leiomyoma extended to the right heart chambers: a compendium of information from isolated reports. Eur J Cardiothorac Surg 19: 522–524

Download references

Author information

Correspondence to Icilma Fergus.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Further reading