Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Atherosclerosis of the ascending aorta as a major determinant of the outcome of cardiac surgery

Abstract

Epiaortic ultrasonography has high sensitivity for the detection of atherosclerosis. In several studies, the technique has identified atherosclerosis of the ascending aorta as the major risk factor for stroke after cardiac surgery. The level of risk depends on the presence, location and extent of disease when the ascending aorta is surgically manipulated. This knowledge enables clinicians to focus on the diagnostic and surgical technique and to consider the various options. Routine use of intraoperative epiaortic ultrasonography should be applied so that surgical manipulation of the ascending aorta can be reduced or, if possible, avoided in patients with atherosclerosis of the ascending aorta. Alternatively, if major manipulation such as clamping must be performed in the presence of severe atherosclerosis, the use of intra-aortic filters could be considered.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Roach GW et al. (1996) Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators. N Engl J Med 335: 1857–1863

    Article  CAS  Google Scholar 

  2. Salazar JD et al. (2001) Stroke after cardiac surgery: short- and long-term outcomes. Ann Thorac Surg 72: 1195–1202

    Article  CAS  Google Scholar 

  3. van der Linden J et al. (2001) Postoperative stroke in cardiac surgery is related to the location and extent of atherosclerotic disease in the ascending aorta. J Am Coll Cardiol 38: 131–135

    Article  CAS  Google Scholar 

  4. John R et al. (2000) Multicenter review of preoperative risk factors for stroke after coronary artery bypass grafting. Ann Thorac Surg 69: 30–36

    Article  CAS  Google Scholar 

  5. Rao V et al. (1995) Risk factors for stroke following coronary bypass surgery. J Card Surg 10 (Suppl): 468–474

    Article  CAS  Google Scholar 

  6. Newman MF et al. (1996) Multicenter preoperative stroke risk index for patients undergoing coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Circulation 94 (Suppl II): 74–80

    Google Scholar 

  7. Ridderstolpe L et al. (2002) Risk factor analysis of early and delayed cerebral complications after cardiac surgery. J Cardiothorac Vasc Anesth 16: 278–285

    Article  Google Scholar 

  8. Blauth CI et al. (1992) Atheroembolism from the ascending aorta. An emerging problem in cardiac surgery. J Thorac Cardiovasc Surg 103: 1104–1112

    CAS  PubMed  Google Scholar 

  9. Davila-Roman VG et al. (1994) Atherosclerosis of the ascending aorta. Prevalence and role as an independent predictor of cerebrovascular events in cardiac patients. Stroke 25: 2010–2016

    Article  CAS  Google Scholar 

  10. Hogue CW Jr et al. (1999) Risk factors for early or delayed stroke after cardiac surgery. Circulation 100: 642–647

    Article  Google Scholar 

  11. Marschall K et al. (1994) Superiority of transesophageal echocardiography in detecting aortic arch atheromatous disease: identification of patients at increased risk of stroke during cardiac surgery. J Cardiothorac Vasc Anesth 8: 5–13

    Article  CAS  Google Scholar 

  12. Konstadt SN et al. (1994) The ascending aorta: how much does transesophageal echocardiography see? Anesth Analg 78: 240–244

    Article  CAS  Google Scholar 

  13. Marshall WG Jr et al. (1989) Intraoperative ultrasonic imaging of the ascending aorta. Ann Thorac Surg 48: 339–344

    Article  Google Scholar 

  14. Davila-Roman VG et al. (1996) Intraoperative transesophageal echocardiography and epiaortic ultrasound for assessment of atherosclerosis of the thoracic aorta. J Am Coll Cardiol 28: 942–947

    Article  CAS  Google Scholar 

  15. Amarenco P et al. (1994) Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Engl J Med 331: 1474–1479

    Article  CAS  Google Scholar 

  16. Sylivris S et al. (1997) The intraoperative assessment of ascending aortic atheroma: epiaortic imaging is superior to both transesophageal echocardiography and direct palpation. J Cardiothorac Vasc Anesth 11: 704–707

    Article  CAS  Google Scholar 

  17. Hangler HB et al. (2003) Modification of surgical technique for ascending aortic atherosclerosis: impact on stroke reduction in coronary artery bypass grafting. J Thorac Cardiovasc Surg 126: 391–400

    Article  Google Scholar 

  18. Lev-Ran O et al. (2005) No-touch aorta off-pump coronary surgery: the effect on stroke. J Thorac Cardiovasc Surg 129: 307–313

    Article  Google Scholar 

  19. Davila-Roman VG et al. (1999) Atherosclerosis of the ascending aorta is an independent predictor of long-term neurologic events and mortality. J Am Coll Cardiol 33: 1308–1316

    Article  CAS  Google Scholar 

  20. Konstadt SN et al. (1995) Transesophageal echocardiography can be used to screen for ascending aortic atherosclerosis. Anesth Analg 81: 225–228

    CAS  PubMed  Google Scholar 

  21. Ura M et al. (2000) Ultrasonographic demonstration of manipulation-related aortic injuries after cardiac surgery. J Am Coll Cardiol 35: 1303–1310

    Article  CAS  Google Scholar 

  22. Bolotin G et al. (2005) Use of intraoperative epiaortic ultrasonography to delineate aortic atheroma. Chest 127: 60–65

    Article  Google Scholar 

  23. SiteRite Ultrasound Systems. [http://www.dymax-usa.com/products.html] (accessed 21 March 2005)

  24. Laas J et al. (1999) Orientation of tilting disc and bileaflet aortic valve substitutes for optimal hemodynamics. Ann Thorac Surg 68: 1096–1099

    Article  CAS  Google Scholar 

  25. Bergman P et al. (2004) Preoperative computed tomography or intraoperative epiaortic ultrasound for the diagnosis of atherosclerosis of the ascending aorta? Heart Surg Forum 7: 245–249

    Article  Google Scholar 

  26. Summers RM et al. (1998) Evaluation of the aortic root by MRI: insights from patients with homozygous familial hypercholesterolemia. Circulation 98: 509–518

    Article  CAS  Google Scholar 

  27. Wimmer-Greinecker G (2003) Reduction of neurologic complications by intra-aortic filtration in patients undergoing combined intracardiac and CABG procedures. Eur J Cardiothorac Surg 23: 159–164

    Article  Google Scholar 

  28. Reichenspurner H et al. (2000) Particulate emboli capture by an intra-aortic filter device during cardiac surgery. J Thorac Cardiovasc Surg 119: 233–241

    Article  CAS  Google Scholar 

  29. Banbury MK et al. (2003) Emboli capture using the Embol-X intraaortic filter in cardiac surgery: a multicentered randomized trial of 1,289 patients. Ann Thorac Surg 76: 508–515

    Article  Google Scholar 

  30. Schmitz C et al. (2003) Can particulate extraction from the ascending aorta reduce neurologic injury in cardiac surgery? J Thorac Cardiovasc Surg 126: 1829–1838

    Article  Google Scholar 

  31. Bergman P et al. (2002) Aortic atheroma is related to number of particulates captured by intra-aortic filtration in CABG. Eur J Cardiothorac Surg 22: 539–544

    Article  Google Scholar 

  32. Sharony R et al. (2004) Propensity case-matched analysis of off-pump coronary artery bypass grafting in patients with atheromatous aortic disease. J Thorac Cardiovasc Surg 127: 406–413

    Article  Google Scholar 

  33. Stamou SC et al. (2002) Stroke after conventional versus minimally invasive coronary artery bypass. Ann Thorac Surg 74: 394–399

    Article  Google Scholar 

  34. Meharwal ZS et al. (2002) Off-pump multivessel coronary artery surgery in high-risk patients. Ann Thorac Surg 74: S1353–1357

    Article  Google Scholar 

  35. Sabik JF et al. (2002) Does off-pump coronary surgery reduce morbidity and mortality? J Thorac Cardiovasc Surg 124: 698–707

    Article  Google Scholar 

  36. Ascione R et al. (2002) Predictors of stroke in the modern era of coronary artery bypass grafting: a case control study. Ann Thorac Surg 74: 474–480

    Article  Google Scholar 

  37. Hoff SJ et al. (2002) Coronary artery bypass in patients 80 years and over: is off-pump the operation of choice? Ann Thorac Surg 74: S1340–1343

    Article  Google Scholar 

  38. Demaria RG et al. (2002) Reduced mortality and strokes with off-pump coronary artery bypass grafting surgery in octogenarians. Circulation 106 (Suppl I): 5–10

    Google Scholar 

  39. Khan NE et al. (2004) A randomized comparison of off-pump and on-pump multivessel coronary-artery bypass surgery. N Engl J Med 350: 21–28

    Article  CAS  Google Scholar 

  40. Legare JF et al. (2004) Coronary bypass surgery performed off pump does not result in lower in-hospital morbidity than coronary artery bypass grafting performed on pump. Circulation 109: 887–892

    Article  Google Scholar 

  41. Calafiore AM et al. (2002) Impact of aortic manipulation on incidence of cerebrovascular accidents after surgical myocardial revascularization. Ann Thorac Surg 73: 1387–1393

    Article  Google Scholar 

  42. Grega MA et al. (2003) Impact of single clamp versus double clamp technique on neurologic outcome. Ann Thorac Surg 75: 1387–1391

    Article  Google Scholar 

  43. Katariya K et al. (2004) Initial experience with sutureless proximal anastomoses performed with a mechanical connector leading to clampless off-pump coronary artery bypass surgery. Ann Thorac Surg 77: 563–568

    Article  Google Scholar 

  44. Bonatti J et al. (2000) The subclavian and axillary arteries as inflow vessels for coronary artery bypass grafts—combined experience from three cardiac surgery centers. Heart Surg Forum 3: 307–311

    CAS  PubMed  Google Scholar 

  45. Kim KB et al. (2002) Off-pump coronary artery bypass with complete avoidance of aortic manipulation. Ann Thorac Surg 74: S1377–1382

    Article  Google Scholar 

  46. Royse AG et al. (2000) Reduced neuropsychological dysfunction using epiaortic echocardiography and the exclusive Y graft. Ann Thorac Surg 69: 1431–1438

    Article  CAS  Google Scholar 

  47. Kapetanakis EI et al. (2004) The impact of aortic manipulation on neurologic outcomes after coronary artery bypass surgery: a risk-adjusted study. Ann Thorac Surg 78: 1564–1571

    Article  Google Scholar 

  48. Bergman P et al. (2004) A policy to reduce stroke in patients with extensive atherosclerosis of the ascending aorta undergoing coronary surgery. Interact Cardiovasc Thorac Surg 38: 28–32

    Article  Google Scholar 

  49. Kouchoukos NT et al. (1994) Management of the severely atherosclerotic aorta during cardiac operations. J Card Surg 9: 490–494

    Article  CAS  Google Scholar 

  50. Gillinov AM et al. (2000) The atherosclerotic aorta at aortic valve replacement: surgical strategies and results. J Thorac Cardiovasc Surg 120: 957–963

    Article  CAS  Google Scholar 

  51. Borger MA et al. (1999) Decreased cerebral emboli during distal aortic arch cannulation: a randomized clinical trial. J Thorac Cardiovasc Surg 118: 740–745

    Article  CAS  Google Scholar 

  52. Hammon JW Jr et al. (1997) Risk factors and solutions for the development of neurobehavioral changes after coronary artery bypass grafting. Ann Thorac Surg 63: 1613–1618

    Article  Google Scholar 

  53. Goto T et al. (2000) Craniocervical and aortic atherosclerosis as neurologic risk factors in coronary surgery. Ann Thorac Surg 69: 834–840

    Article  CAS  Google Scholar 

  54. Hogue CW Jr et al. (1999) Neurological complications of cardiac surgery: the need for new paradigms in prevention and treatment. Semin Thorac Cardiovasc Surg 11: 105–115

    Article  Google Scholar 

  55. Barbut D et al. (1997) Aortic atheroma is related to outcome but not numbers of emboli during coronary bypass. Ann Thorac Surg 64: 454–459

    Article  CAS  Google Scholar 

  56. Calafiore AM et al. (2001) Early clinical experience with a new sutureless anastomotic device for proximal anastomosis of the saphenous vein to the aorta. J Thorac Cardiovasc Surg 121: 854–858

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Per Bergman.

Ethics declarations

Competing interests

P Bergman and J van der Linden have been members of the International Council of Emboli Management (ICEM) Study Group, which was sponsored by EMBOL-X Inc, Mountain View, CA, who manufacture intra-aortic filters

Glossary

TYPE I NEUROLOGIC INJURY

Focal injury, stupor or coma at discharge from hospital

EPIAORTIC ULTRASONOGRAPHY

Ultrasound scanning in which the transducer is placed directly on the aorta to assess atherosclerosis

HARD-SHELL STANDOFF

Part of the probe that distances the ultrasonic transducer from the aorta to enable sharp focus of surface structures very close to the device tip

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bergman, P., van der Linden, J. Atherosclerosis of the ascending aorta as a major determinant of the outcome of cardiac surgery. Nat Rev Cardiol 2, 246–251 (2005). https://doi.org/10.1038/ncpcardio0192

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpcardio0192

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing