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Reversible cardiomyopathy caused by administration of interferon α

Nature Clinical Practice Cardiovascular Medicine volume 2, pages 53–57 (2005)Cite this article

Abstract

Background A 56-year-old man with normal cardiac function received treatment with interferon α-2b for malignant melanoma. Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion. Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough. Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction.

Investigations Echocardiogram, electrocardiogram, serum chemistries, coronary angiography, right-heart and left-heart catheterization and endomyocardial biopsy.

Diagnosis Interferon α-2b-induced cardiomyopathy.

Management Intravenous dobutamine and dopamine for cardiogenic shock and discontinuation of interferon α-2b.

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Figure 1: Electron microscopy demonstrating interferon-induced tubuloreticular inclusions
Figure 2: Endomyocardial biopsy demonstrating borderline myocarditis

References

  1. Grimley PM et al. (1985) Tubuloreticular inclusions in peripheral blood mononuclear cells related to systemic therapy with alpha-interferon. Lab Invest 52: 638–649

    CAS  PubMed  Google Scholar 

  2. Felker GM et al. (2000) Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med 342: 1077–1084

    Article  CAS  Google Scholar 

  3. Klein I and Ojamaa K (2001) Thyroid hormone and the cardiovascular system. N Engl J Med 344: 501–509

    Article  CAS  Google Scholar 

  4. Midroni G et al. (2000) Endoneurial vasculitis and tubuloreticular inclusions in peripheral nerve biopsy. Clin Neuropathol 19: 70–76

    CAS  PubMed  Google Scholar 

  5. Deyton LR et al. (1989) Reversible cardiac dysfunction associated with interferon alfa therapy in AIDS patients with Kaposi's sarcoma. N Engl J Med 321: 1246–1249

    Article  CAS  Google Scholar 

  6. Sacchi S et al. (1995) Immune-mediated and unusual complications during interferon alfa therapy in chronic myelogenous leukemia. J Clin Oncol 13: 2401–2407

    Article  CAS  Google Scholar 

  7. Roti E et al. (1996) Multiple changes in thyroid function in patients with chronic active HCV hepatitis treated with recombinant interferon-alpha. Am J Med 101: 482–487

    Article  CAS  Google Scholar 

  8. Aretz HT et al. (1987) Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol 1: 3–14

    CAS  PubMed  Google Scholar 

  9. Brassard DL et al. (2002) Interferon-alpha as an immunotherapeutic protein. J Leukoc Biol 71: 565–581

    CAS  PubMed  Google Scholar 

  10. Ardehali H et al. (2004) Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathy. Am Heart J 147: 919–923

    Article  Google Scholar 

Download references

Acknowledgements

The authors thank Kenneth L Baughman for advice on this manuscript. This work was supported in part by the Johns Hopkins DW Reynolds Foundation.

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Authors and Affiliations

  1. Division of Cardiology,

    Aarif Y Khakoo, Marc K Halushka, J Eduardo Rame, E Rene Rodriguez, Edward K Kasper & Daniel P Judge

  2. Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Aarif Y Khakoo, Marc K Halushka, J Eduardo Rame, E Rene Rodriguez, Edward K Kasper & Daniel P Judge

Authors
  1. Aarif Y Khakoo
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  2. Marc K Halushka
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  3. J Eduardo Rame
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  4. E Rene Rodriguez
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  5. Edward K Kasper
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  6. Daniel P Judge
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Corresponding author

Correspondence to Daniel P Judge.

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The authors declare no competing financial interests.

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Cite this article

Khakoo, A., Halushka, M., Rame, J. et al. Reversible cardiomyopathy caused by administration of interferon α. Nat Rev Cardiol 2, 53–57 (2005). https://doi.org/10.1038/ncpcardio0069

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  • DOI: https://doi.org/10.1038/ncpcardio0069

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