Figure 3 : EPPS does not affect synaptic plasticity in mice.

From: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

Figure 3

EPPS, 0 (EPPS) or 30 mg kg-1 per day (EPPS++), was orally given to WT (n=4) and APP/PS1 TG (n=4) mice for 5 days. (ad) LTP, measured by % field EPSP% fEPSP slope, in CA1 of hippocampal slices (three slices per mouse) from WT mice. (a) Upper trace, a representative trace of fEPSP before and after inducing LTP by pairing stimuli in CA1 of the hippocampus in non-treated mice. Lower trace, a time course of EPSP before and after inducing LTP by pairing stimuli in CA1 of the hippocampus in non-treated mice. (b) Upper trace, a representative trace of EPSP before and after inducing LTP by pairing stimuli in CA1 of the hippocampus (three slices per mouse) in EPPS-treated mice. (c) Averaged time course of EPSP before and after inducing LTP by pairing stimuli in CA1 of the hippocampus in non-treated and EPPS-treated mice. (d) Quantification of the effect of EPPS on LTP. (eh) LTP, measured by the % fEPSP slope, in CA1 of hippocampal slices from TG mice. (e) Upper trace, a representative trace of EPSP before and after inducing LTP by pairing stimuli in CA1 of the hippocampus in non-treated mice. Lower trace, a time course of EPSP before and after inducing LTP by pairing stimuli in CA1 of the hippocampus in non-treated mice. (f) Upper trace, a representative trace of EPSP before and after inducing LTP by pairing stimuli in CA1 of the hippocampus in EPPS-treated mice. (g) Averaged time course of EPSP before and after inducing LTP by pairing stimuli in CA1 of the hippocampus in saline-treated and EPPS-treated mice. (h) Quantification of EPPS effect on LTP in TG mice. LTP was induced by theta burst stimulation (TBS), represented by the arrow. The error bars represent the s.e.m. Student’s unpaired t-tests were performed in statistical analyses; comparisons were not significant (P>0.05).