Table 1: Insulin at physiological concentrations (30 nM) increases Vmax for DAT-mediated uptake in striatal slices.

From: Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

Vmax (μM s−1)
 ControlnInsulin (30 nM)nInsulin (100 nM)n
NAc shell0.88±0.04251.09±0.09*210.82±0.0523
 R2=0.9125 R2=0.9392 R2=0.9014 
NAc core2.06±0.07732.32±0.08*612.20±0.0836
 R2=0.9937 R2=0.9929 R2=0.9912 
CPu3.23±0.08623.63±0.15*403.39±0.0929
 R2=0.9902 R2=0.9924 R2=0.9946 
  1. Vmax values for DAT-mediated uptake after evoked striatal DA release were determined from evoked [DA]o records using a fixed Km of 0.2 μM for all regions and conditions. Data are means±s.e.m, n, number of sites, R2 indicates goodness of fit (*P<0.05 versus control, one-way ANOVA followed by Dunnett’s post hoc test).