Figure 3 : Insulin-induced increases in evoked [DA]o are enhanced by FR and lost in OB.

From: Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

Figure 3

(a) Plasma insulin concentration is positively correlated with body weight across feeding groups (R=0.76). (b) Average single-pulse-evoked [DA]o in NAc core (see Supplementary Fig. 2a,b for NAc shell and CPu) was lower in FR (38±4%) and OB (25±4%) versus AL (n=50–60 sites from 5–6 rats per diet group, F2,156=23.337, one-way ANOVA, Tukey HSD; ***P<0.001); OB versus FR (P<0.08). (c) Sensitivity of evoked [DA]o to insulin was enhanced in FR, but lost in OB (n=21–49 sites per subregion per concentration from 2–4 rats per diet group, one-way ANOVA, Tukey HSD), with greater sensitivity in FR versus AL rats in all subregions (P<0.001 for each region; two-way ANOVA; CPu: F(conc × diet; 3,286)=10.253; core: F(conc × diet; 3,353)=6.166; shell: F(conc × diet; 3,195)=10.735).