Figure 6: STOML3 modulates Piezo1 channel’s surrounding membrane mechanics via association with cholesterol. | Nature Communications

Figure 6: STOML3 modulates Piezo1 channel’s surrounding membrane mechanics via association with cholesterol.

From: Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons

Figure 6

(a) Quantitative comparison of elasticity modulus E1 and E2 values obtained by fitting procedure in HEK293 cells treated with or without MβCD (control: n=16; MβCD: n=17; two-way ANOVA with post hoc Bonferroni’s test, P<0.0001). (b) Quantitative comparison of elasticity modulus E1 and E2 values obtained by fitting procedure in HEK293 cells expressing STOML3 or STOML3-P40 (STOML3: n=25; STOML3-P40: n=23; two-way ANOVA with post hoc Bonferroni’s test, P<0.0001). (c) Quantitative comparison of elasticity modulus E1 and E2 values obtained by fitting procedure in HEK293 cells expressing STOML3 or STOML3-P40 in the presence of Piezo1 channel (Piezo1+STOML3: n=59; Piezo1+STOML3-P40: n=75; two-way ANOVA with post hoc Bonferroni’s test, P<0.0001). *P<0.05, ****P<0.0001. Error bars indicate s.e.m.

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