Figure 5: Premature bivalent separation into univalents precedes age-related chromosome segregation errors during MI. | Nature Communications

Figure 5: Premature bivalent separation into univalents precedes age-related chromosome segregation errors during MI.

From: Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

Figure 5

Bivalents with weakened cohesion in aged oocytes undergo hyperstretching and separation into univalents by microtubule-mediated bipolar spindle forces. This bipolar forces in turn biorient the sister KTs of the univalents. The univalents are therefore strongly biased towards predivision of sister chromatids, including balanced predivision. After balanced predivision during MI, the chromatids undergo random segregation during MII.

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