Figure 1: Regulation of fly glucose and trehalose in response to environmental and genetic perturbations. | Nature Communications

Figure 1: Regulation of fly glucose and trehalose in response to environmental and genetic perturbations.

From: Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism

Figure 1

(a) Circulating glucose (left) and trehalose (right) levels were measured in mid-third instar w1118 larvae cultured in various density conditions. n=4 each (10 larvae per replicate). (b) Quantification of feeding rates of w1118 larvae cultured in various density conditions. n=3 each (30 larvae per replicate). (c) w1118 larvae were provided 5% and 20% sucrose solutions and after 1 or 4 h, glucose (left) and trehalose (right) levels were measured. n=4 each (10 larvae per replicate). (d) w1118 controls were provided water and 5% sucrose and after 4 h, glucose and trehalose levels were measured. n=4 each (10 larvae per replicate). (e) Glucose and trehalose levels of P-element mutants for three mammalian glucose regulatory proof-of-principle genes. n=4 each (10 larvae per replicate). Error bars indicate s.e.m. Statistical significance was assessed by two-tailed Student’s t-test, *P<0.05, **P<0.01, ***P<0.001.

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