Radical cascade reaction of alkynes with N-fluoroarylsulfonimides and alcohols

Cascade reactions initiated by radical addition to alkynes are synthetically very attractive because they enable access to highly complex molecular skeletons in only few synthetic steps under usually mild conditions. Here we report a general radical cascade reaction of alkynes, N-fluoroarylsulfonimides and alcohols, enabling the efficient synthesis of important α-amino-α-aryl ketones from readily available starting materials via a single operation. During this process, the highly regioselective nitrogen-centred radical addition to internal and terminal alkynes generating vinyl radicals and the next explicit migration of aryl group from the nitrogen source lead the following efficient desulfonylation, oxygenation, and semi-pinacol rearrangement. In addition, the semi-pinacol rearrangement precursors, α-alkyloxyl-α,α-diaryl imines, could also be efficiently obtained under milder conditions. This methodology might open a new entry for designing intermolecular radical cascade reaction of alkynes.

T he regioselective construction of C-N bond under mild conditions remains an attractive research field due to the ubiquitous presence of amines in both naturally occurring and synthetic compounds, which manifest high levels of biological activity 1,2 . Alkyne functionalization, the addition of functional groups across a triple bond, exemplifies a class of reactions with significant synthetic potential. Accordingly, direct amination reaction of simple alkynes involving general intermolecular C-N bond construction step, such as hydroamiantion [3][4][5][6] , diamination 7,8 , aminooxygenation 9-12 , aminohalogenation 13,14 and aminoacylation 15 have been successfully developed, during which nucleophilic amination was usually involved with a few strategies employing electrophilic nitrogen sources (Fig. 1a). Cascade reactions initiated by radical addition to alkynes are synthetically very attractive because they allow access to highly complex molecular skeletons in only few synthetic steps under usually mild conditions, enabling them to exhibit high functional group compatiblity 16 . Although intermolecular radical addition to alkynes generating reactive vinyl radicals to perform intramolecular cascade reactions have been well established, their intermolecular multi-component equivalents remain a formidable challenge (vide infra). It is thus not surprising in that light that even simple addition reactions of nitrogen-centred radicals to alkynes are very rare 17,18 . In fact, compared with the well-established nucleophilic and electrophilic amination reaction, the construction of C-N bonds based on nitrogen-centred radicals have not received sufficient attention. The highly reactive vinyl radical generated by the addition of nitrogen-centred radical to alkynes offers a unique platform for radical-based processes mechanistically distinct from ionic pathways. We anticipate that this novel bond-forming strategy could be harnessed for facile construction of otherwise challenging nitrogen containing molecular architectures with traditional methodologies.
Challenges for the development of general cascade reactions initiated by nitrogen-centred radical addition to alkynes mainly resulted from two reasons: (1) the usually harsh conditions for the generation of nitrogen-centred radicals and their leading   propensity for hydrogen abstraction or engaging in other degradation pathway; (2) the lack of a general intramolecular trapping manner to transfer the highly reactive incipient vinyl radical for further intermolecular cascade design. Recently, we developed copper-catalysed aminocyanation, diamination and aminoflurination reaction of alkenes via the efficient generation of nitrogen-centred radical from N-fluorobenzenesulfonimide (NFSI) under mild conditions 19,20 . As part of our continuing interest in employing NFSI as efficient amination nitrogen source [21][22][23][24] , in this article, a novel aminative multifunctionalization cascade reaction of alkyne with N-fluoroarylsulfonimide (as both nitrogen and aryl source) and alcohol (as oxygen source) was developed. Utilizing this simple transformation, a-amino-aaryl ketones could be efficiently synthesized from both terminal and internal alkynes (Fig. 1b). a-Amino-a-aryl ketones, such as N-methylwelwitindolinone C isothiocyanate 25 , ketamine 26 and prasugrel 27 belong to an important class of biologically active natural products and pharmaceuticals. They are also useful precursors for the synthesis of heterocycles 28-31 and 1,2-amino alcohols 32,33 . Recently, starting from readily available substrates, interesting methods for a-amino-a-aryl ketones such as cross-aza benzoin reaction of aldehydes with aryl imines [34][35][36][37][38] and acylointype cross-coupling of aryl imines with nitriles 39 were developed. Although significant progress has been made in the formation of C-N 40-43 and C-C(aryl) [44][45][46][47][48] bonds at a-position of the carbonyl group, it is a great challenge to simultaneously form C-N and C-C(aryl) bonds especially for the construction of quaternary carbon centres. Herein, we report a cascade reaction that offers highly efficient construction of a-amino-a-aryl ketones starting from readily available alkynes, N-fluoroarylsulfonimides and alcohols via a highly efficient sequential regioselective nitrogen-centred radical addition to alkyne/aryl migration/desulfonylation/oxygenation/ semi-pinacol rearrangement process (Fig. 1b). In addition, the semi-pinacol rearrangement precursors, a-alkyloxyl-a,a-diaryl imines, could also be efficiently obtained under milder conditions.

Results
Optimization for the sythesis of a-amino-a-aryl ketones. On the basis of previous reports developed by us 19,20 and others [49][50][51] , we sought to use NFSI as both nitrogen source and aryl source to investigate aminative multifunctionalization of alkynes. Our investigation commenced with the reaction of phenylacetylene (1a, 0.5 mmol) with NFSI (0.75 mmol, 1.5 equiv.) in the presence of Cu(OTf) 2 (10 mol %) at 90°C in commercially available CH 3 CN (2 ml) under N 2 atmosphere, a-amino-a-aryl ketone 2a was obtained in 30% yield after 8 h. However, when dry CH 3 CN was used, no reaction occurred. Therefore, water (1.5 mmol, 3 equiv.) was added to the reaction system, a-amino-a-aryl ketone 2a was obtained in 37% yield. In this reaction, C-N, C-C(aryl) and C ¼ O bonds were simultaneously introduced to alkyne 1a. Delightfully, the readily available CH 3 OH was viable and furnished 2a in 58% yield (Table 1, entry 1). With pyridine-N-oxide or CH 3 COOH as oxygen source, no 2a was obtained. So the reaction of 1a with NFSI and CH 3 OH was used as the model to optimize the reaction conditions. As shown in Table 1, other catalysts, such as CuCl, Fe(OTf) 2 , Zn(OTf) 2 and Sc(OTf) 3 could catalyse the reaction, but no improved result was obtained ( Scope of terminal alkyne and N-fluoroarylsulfonimide substrates. With the optimized conditions at hand (Table 1, entry 14), the scope of aminative multifunctionalization of terminal alkynes was investigated. The tested phenylethetylene derivatives 1 smoothly reacted with NFSI and CH 3 OH to afford the corresponding a-amino-a-aryl ketones 2 or 3 in 48-78% yields ( Table 2). For a-amino-a-aryl ketones 2, phenyl group from NFSI connected to the terminal carbon of alkynes and for a-amino-a-aryl ketones 3, aryl group from alkynes 1 connected to the terminal carbon of alkynes. For alkynes 1b-1f which bear ortho-substitutions, 2b-2f became the major products with the less sterically hindered phenyl group selectively migrated, forming C À C (aryl) bonds. Alkynes 1g-1o with electron donating or withdrawing groups afforded major products 2g-2i and 3j-3o in which the comparatively electron-rich aromatic ring migrated to form C À C (aryl) bonds. In addition, NFR1 (N-fluoro-4-methyl-Ntosylbenzenesulfonamide) was used instead of NFSI to further explore the scope of this alkyne aminative multifunctionalization. As expected, the reaction of 1 with NFR1 and CH 3 OH proceeded smoothly and provided 4a-h and 5a-h (with 4a-h as major products) in 48-84% yield (Table 3). Similar electronic and steric effects as using NFSI were observed. Trifluoromethyl and cyano groups were compatible and provided the corresponding a-amino-a-aryl ketones 4g (81%) and 4h (48%). However, substrates with strong electron-donating groups on the aromatic ring, such as 1-ethynyl-4-methoxybenzene and 1-ethynyl-3methoxybenzene, were not effective. In addition, reactions between 1-(tert-butyl)-4-ethynylbenzene and some other NFSI derivatives were also explored to extend scope and investigate electronic effect of aryl part of NFSI derivatives. For 4-chloro-     , the corresponding a-amino-a-aryl ketones were obtained in 72 and 67% yield, respectively. These results showed that the transformation was more efficient for electron-rich aromatic rings than electronpoor aromatic rings in NFSI derivatives. The halogen atom on the aromatic ring was tolerated in this process (2e-i, 4c-f, 5i, 5k), offering an opportunity for further elaboration.
Scope of internal alkyne substrates. To examine the generality of this alkyne aminative multifunctionalization, internal alkynes were subsequently examined. In the presence of 5 mol% CuCN, the reaction of pent-1-yn-1-ylbenzene (6a, 0.5 mmol), NFSI (1.5 equiv., 0.75 mmol) and i-PrOH (1.5 equiv., 0.75 mmol) in dichloromethane (DCM, 2 ml) was carried out at 70°C under nitrogen atmosphere for 12 h. The expected a-amino-a-aryl ketone 8a with a quaternary carbon at a-position was afforded in 68% yield ( Table 4). As shown in Table 4, an array of a-amino-aaryl ketones 8 and/or 9 were obtained in yields ranging from 48 to 73%. Similarly, preferential migration of electron-rich aromatic substituent (aryl on the alkyne versus Ph from NFSI) was observed in the product distribution. It should be noted that this aminative multifunctionalization of internal alkynes directly lead to the skeleton of a-tertiary amine derivatives, which are widespread in various natural products and bioactive compounds [52][53][54][55] . Quaternary carbon centres with a nitrogen substituent have been successfully constructed through molecular rearrangement 56 . However, special structures of substrates were necessary. Therefore, the directly aminative multifunctionalization of alkynes could provide a new and facile way for a-tertiary amines. Recently, Murakami and co-workers 57 reported an interesting Cu-and Rh-catalyzed aminative multifunctionalization of terminal alkynes to form a-amino-a-allyl ketones via a-imino metal carbene intermediate, during which C-C(allyl) bond formed through Claisen-type rearrangement. In their study, for internal alkynes, N-sulfonyl-1,2,3-triazoles needed to be pre-prepared.
Mechanism investigation. Radical scavengers were employed to probe the mechanism of the aminative multifunctionalization of alkynes. Formation of 2a was completely inhibited when 1 equivalent of 2,6-di-tert-butyl-4-methylphenol or 2,2,6,6-tetramethyl-1-piperidinyloxy was added to the reaction. For the reaction with 2,6-di-tert-butyl-4-methylphenol as radical scavenger, 26% benzylic C-H amination product was obtained. These results suggested a possible radical mechanism. In combination with our previous finding in amination [19][20][21][22][23][24] , we proposed a possible mechanism as depicted in Fig. 2. Initially, the in situ-generated nitrogen-centred radical A added to the triple bond of alkyne (for example 6g) regioselectively, providing a highly reactive vinyl radical B. Subsequently, sequential intramolecular 1,4-aryl migration via 5-ipso cyclization and desulfonylation would produce amidyl radical C 58-61 . This imidyl radical exists at an equilibrium with its resonance structure a-imino carbon radical D which could be stabilized by two aromatic rings and a C ¼ N double bond. Then, the single-electron oxidation of intermediate D by NFSI generated a carbocation intermediate E and a nitrogencentred radical A to continue the next catalytic cycle. The reaction between intermediate E and ROH provided a-alkyloxyl imine F. Finally, the protonation and semi-pinacol rearrangement of intermediate F furnished aminative multifunctionalization to provide isomer 8g and 9g. The ratio of 8g to 9g depended on electronic and steric effects of the corresponding aromatic substituents. As depicted in Tables 2-4, electron-rich and the sterically less-hindered aromatic rings are more prone to migrate, which is in consistency with the requirements of semi-pinacol rearrangement. It is noted that during this transformation, trapping of the incipient vinyl radical by aromatic ring from nitrogen source was a key step leading to intermolecular cascade process, which might provide a new entry to design radical addition initiated multi-component cascade reaction of alkynes.
Since the above-mentioned mechanism invoked a semi-pinacol rearrangement from a relatively stable species a-alkyloxyl-a,adiaryl imine F to the final product, we questioned if this species could be obtained separately with modification of reaction parameters. Recently, semi-pinacol rearrangement of a-hydroxy imines had been successfully applied in natural product as well as catalytic asymmetric syntheses [62][63][64] . To our delight, the reaction  of pent-1-yn-1-ylbenzene (6a, 0.5 mmol), NFSI (1.0 mmol, 2.0 equiv) and propan-2-ol (1.5 mmol, 3.0 equiv.) in the presence of Cu(acac) 2 (5 mol %) at 0°C in dry CH 3 CN (2 mL) under N 2 atmosphere was performed for 48 h, a-alkyloxyl-a,a-diaryl imine 7a was obtained in 71% yield. Besides the reaction temperature, catalyst played an important role in obtaining this product because no desired 7a was obtained without copper. As shown in Table 5, various alcohols could react with NFSI and alkynes to obtain the corresponding a-alkyloxyl-a,a-diaryl imine 7a-7j in 46-71% yields. It should be noted that diaryl-substituted alkynes are also effective. Starting from 1,2-diphenylethyne (6k), the corresponding a-alkyloxyl-a,a-diaryl imine was obtained in 66% under relatively higher temperature (Table 5, entry 11). Interestingly, for substrate 6l, nitrogen-centred radical highly regioselectively added to the alkyne carbon connected to the aromatic ring with strong electron-withdrawing NO 2 group. From substrates 6m and 6n, regioisomer mixtures (7m:7m 0 ¼ 1.5:1, 7n:7n 0 ¼ 1:2) were obtained. Identification of intermediate F (Fig. 1) provided strong proof to the proposed mechanism. Therefore, further experiments for more mechanistic information were also carried out. The final a-amino-a-aryl ketone 8a could be obtained in 87% yield when heating 7a (0.3 mmol) at 70°C in the presence of 0.3 mmol trifluoroacetic acid (TFA) in 2 ml DCM for 4 h, lending further support for 7 as the key intermediate in the novel aminative multifunctionalization of alkynes. However, under the same conditions but adding CuCN (5 mol %) instead of TFA, no reaction occured. Instead, when ZnCl 2 (10 mol%) was added, 8a was isolated in 60% yield, which showed that ZnCl 2 additive in Table 4 played an important role for the transformation from intermediate F (Fig. 2) to final a-amino-a-aryl ketones. When the semi-pinacol rearrangement of 7a was performed in the presence of HF acid (1 equiv., 40 wt % in water) instead of TFA, 8a could be obtained in 68% yield, along with identified side-product 2-fluoropropane (H, Fig. 2). Starting from 7l, the next semipinacol rearrangement process was not effective, which elucidated why transformation from diaryl-substituted alkynes to the desired a-amino-a-aryl ketones could not be realized in this study. Starting from 6a, when t-BuOH was employed instead of i-PrOH under otherwise same conditions described in Table 5, entry 9, a a-fluoro-a,a-diaryl imine could be obtained in 36% yield, which demonstrated the possible presence of intermediate E (Fig. 2).
In conclusion, an unprecedented cascade radical aminative multifunctionalization reaction of various aryl terminal and internal alkynes with N-fluoroarylsulfonimides and simple alcohols is developed. This methodology provides a new facile and straightforward way for both a-amino-a-aryl ketones and a-alkyloxyl-a,a-diaryl imines, especially for the construction of quaternary a-amino ketones, which might open a new entry for designing multi-component radical cascade reactions of alkynes. Further studies for the application of this transformation are ongoing in our laboratory.

Methods
General methods. For 1 H, 19 F and 13 C NMR spectra of compounds in this manuscript, see Supplementary Figs 1-121. For details of the synthetic procedures, tables including detail experimental, see Supplementary Information.

Preparation of 2a.
To a solution of the NFSI (0.75 mmol, 236.5 mg) in CH 3 CN (2.0 ml) was added the CH 3 OH (1.5 mmol, 61 ml), TFA (0.5 mmol, 37 ml), 1-Phenylethyne (1a, 0.5 mmol, 54 ml) and Cu(OTf) 2 (0.05 mmol, 18.1 mg) in screw-cap test tube under N 2 atmosphere. The test tube was then sealed off with a screw-cap and the reaction mixture was stirred at 70°C for 5.0 h. After the reaction finished, the reaction mixture was cooled to room temperature and quenched by water. The mixture was extracted with CH 2 Cl 2 (3 Â 5.0 ml), the combined organic phases were dried over anhydrous Na 2 SO 4 and the solvent was evaporated under vacuum. The residue was purified by column chromatography (petroleum ether/ ethyl acetate (10:1 v/v)) to give the corresponding product 2a (136.9 mg, 78%).
Preparation of 8a. To a solution of the NFSI (0.75 mmol, 236.5 mg) in CH 2 Cl 2 (2.0 ml) was added the isopropanol (0.75 mmol, 57 ml), but-1-yn-1-ylbenzene (6a, 0.5 mmol, 80 ml), ZnCl 2 (0.01 mmol, 1.4 mg) and CuCN (0.025 mmol, 2.2 mg) in screw-cap test tube under N 2 atmosphere. The test tube was then sealed off with a screw-cap and the reaction was stirred at 70°C for 12.0 h. After the reaction finished, the reaction mixture was cooled to room temperature and quenched by water. The mixture was extracted with CH 2 Cl 2 (3 Â 5.0 ml), the combined organic phases were dried over anhydrous Na 2 SO 4 and the solvent was evaporated under vacuum. The residue was purified by column chromatography (petroleum ether/ ethyl acetate 10:1 (v/v)) to give the corresponding product 8a (133.7 mg, 68%).
Preparation of 7a. To a solution of the NFSI (1.0 mmol, 314.3 mg) in CH 3 CN (2.0 ml) was added the isopropanol (1.5 mmol, 114 ml), but-1-yn-1-ylbenzene (6a, 0.5 mmol, 80 ml) and Cu(acac) 2 (0.025 mmol, 6.5 mg) in screw-cap test tube under N 2 atmosphere. The test tube was then sealed off with a screw-cap and the reaction was stirred at 0°C for 48.0 h. After the reaction finished, the reaction mixture was quenched by water. The mixture was extracted with CH 2 Cl 2 (3 Â 5.0 ml), the combined organic phases were dried over anhydrous Na 2 SO 4 and the solvent was evaporated under vacuum. The residue was purified by column chromatography (petroleum ether/diethyl ether (25:1 v/v)) to give the corresponding product 7a (154.5 mg, 71%).
Preparation of 7k. To a solution of NFSI (1.0 mmol, 315.3 mg) in CH 2 Cl 2 (2.0 ml) was added methanol (1.5 mmol, 61 ml), 1,2-diphenylethyne (6k, 0.5 mmol, 89 mg) and CuCN (0.025 mmol, 2.2 mg) in screw-cap test tube under N 2 atmosphere. The test tube was then sealed off with a screw-cap and the reaction was stirred for the 48.0 h at 90°C. After the reaction finished, the reaction mixture was cooled to room temperature and quenched by water. The mixture was extracted with CH 2 Cl 2 (3 Â 5.0 ml), the combined organic phases were dried over anhydrous Na 2 SO 4 and the solvent was evaporated under vacuum. The residue was purified by column chromatography (petroleum ether/ethyl acetate 20:1 (v/v)) to give the corresponding product 7k (145.6 mg, 68%).