Figure 4 : Anaesthesia preferentially reduces neuronal 2DG-IR uptake.

From: Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

Figure 4

(a) Left: representative 14C-2DG autoradiographs of awake and anaesthetized mice. Right: quantifications of glucose consumption based on 14C-2DG autoradiography in the cortex of awake and ketamine/xylazine-anaesthetized mice. P=0.001, t-test (N=5). (b) Left: imaging of 2DG-IR in the cortex of awake and mice anaesthetized with ketamine 100 mg kg−1 and xylazine 10 mg kg−1, intraperitoneally (i.p.; KX). Scale bars, 20 μm. Right: anaesthesia reduced the ratio of neuronal versus astrocytic 2DG-IR uptake in the cortex. P=0.002, Mann–Whitney test, N=9 awake, N=6, anaesthetized. Bar graphs represent mean±s.e.m.