Figure 1 : Evolutionary trajectories and gene prevalence.

From: Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations

Figure 1

(a) During evolution to ESS1 (Evolutionary Stable State 1), the genes highlighted in green conferred increased fitness depending on the starting initial phenotype. The genes circled in red, such as gene 1, reduce both fecundity and survivorship and were never observed in the final simulated cancer populations. (b) Multiple evolutionary trajectories exist to ESS1 depending on the initial phenotype. This functional equivalence results in genetic heterogeneity within and between patients as seen in c. (c) The mutation prevalence varies greatly depending on the initial phenotype. The orange line represents the neutral mutation prevalence.