Figure 2: In vitro siRNA delivery activity of lipidoid nanoparticles. | Nature Communications

Figure 2: In vitro siRNA delivery activity of lipidoid nanoparticles.

From: Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Figure 2

(a) Relative luciferase activity values (normalized to controls) are shown for 1,400 lipidoids. ~7% of the library induced >50% gene silencing (shown in red). s.d. (not depicted for the sake of clarity) averaged 0.05 (n=4). (b) The tail length, (c) tail substitution number and (d) alkyl-amine composition influenced in vitro activity. Structural features that were common among efficacious materials had positive Relative Hit Rate values.

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