Figure 4 : Mutational processes operative in multiple myeloma.

From: Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

Figure 4

(a,b) Fraction of contribution of each mutation type at each context for the two mutational signatures identified by NMF analysis. The major components contributing to each signature are highlighted with arrows. (c) Stacked bar chart showing the percentage contribution of the two mutational processes identified by NMF to the total number of variants present in each case. Dark blue bars=Signature B, light blue bars=Signature A. (d) In two examples of branching evolution, PD4283 and PD4301, the percentage contribution of the two mutational processes identified by NMF to the variants present in the early sample (dark purple box) was compared with that of the new variants in the late sample (orange box). A stacked bar chart shows that the contribution from Signature B increases significantly in the ‘late’ variants (χ2 test). Dark blue bars=Signature B, light blue bars=Signature A.