Figure 5: Intestine-specific FXR deletion increases lipid oxidation and decreases serum sphingolipids. | Nature Communications

Figure 5: Intestine-specific FXR deletion increases lipid oxidation and decreases serum sphingolipids.

From: Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Figure 5

(a) qPCR analysis of fatty-acid trafficking-related genes in the intestinal mucosa of Fxrfl/fl mice and FxrΔIE mice on a HFD for 14 weeks. Expression was normalized to 18S. n=5 mice per group. (b) qPCR analysis of fatty-acid trafficking- and mobilization-related genes in the intestinal mucosa of Fxrfl/fl mice and FxrΔIE mice on a HFD for 14 weeks. Expression was normalized to 18S RNA. n=5 mice per group. (c) Lipidomics profile of serum sphingomyelin (SM) of Fxrfl/fl mice and FxrΔIE mice on a HFD for 14 weeks. All data are presented as mean±s.d., ANOVA followed by two-tailed Student’s t-test. *P<0.05, **P<0.01 compared with Fxrfl/fl mice. (d) Lipidomics profile of serum SM after tempol treatment on a HFD for 17 weeks. n=5 mice per group. Data are presented as mean±s.d., ANOVA followed by two-tailed Student’s t-test. *P<0.05, **P<0.01 compared with vehicle-treated mice.

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