Figure 4 : Antagonistic pleiotropy can prevent selective sweeps of beneficial CRs.

From: Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy

Figure 4

(a) Scheme of the evolution assay. The rearrangement T4 was mixed with its parental ura4+ marked with GFP (Control-GFP) at a frequency of 25%. The mixture was evolved asexually for 3 days or 15 mitotic generations (no mating). In parallel, the same mixture was first grown in ME to induce random mating and meiosis (With mating). Meiotic products were germinated and further propagated for 15 generations of mitotic growth. Additional details can be found in the Supplementary Information. (b) Frequency of the rearrangement and Control-GFP strains in competition experiments. The graph represents the average of at least four replicates, which are displayed in supplementary Fig. S9. The top graphs show evolution in YES while the bottom graphs in YES+3% EtOH. Both environments are beneficial for the CR in relation to Control-GFP strain.