Figure 3 : Chromosome structure is a selectable trait.

From: Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy

Figure 3

(a) Selective coefficients relative to the parental ura4+ strain grown in rich media (YES) with and without 3% EtOH. Some CRs improve fitness relative to the parental, others are neutral or deleterious. Averages were calculated from >10 independent experiments each with two independent clones. These clones were generated by independent Cre-loxP recombination events to minimize additional mutations and off-target effects. Error bars represent 2 × s.e. (***P<0.001, **P<0.01 and *P<0.05 according to Mann–Whitney U-test). (b) Mitotic fitness in multiple environments of strains containing CRs. Modified strains display strong genotype by environment interactions. Selection coefficients are relative to parental ura4+ strain. Coloured boxes represent average selection coefficient of designated CRs in each environment according to the scale represented at the bottom. Averages were calculated from >10 independent experiments each with two independent clones. Environments were ordered by increased variance in fitness.