Figure 3: Ranking ovarian cancer cell lines by suitability as HGSOC models. | Nature Communications

Figure 3: Ranking ovarian cancer cell lines by suitability as HGSOC models.

From: Evaluating cell lines as tumour models by comparison of genomic profiles

Figure 3

Both average properties (left) and selected genetic events specific to ovarian cancer (right) can be used to distinguish better and poorer models of HGSOC. Average properties include the histological subtype as determined in the original publication (references in Supplementary Data S1), the citation frequency in the literature as estimator of frequency of use in laboratories, the altered fraction of the genome, the number of mutations per million bases and the correlation with the mean CNA profile of HGSOC tumour samples. The selected genetic events include alterations recurrently found either in HGSOC (mutation of TP53, BRCA1 or BRCA2; amplification of C11orf30 (EMSY), CCNE1, KRAS or MYC; mutation or deletion of RB1) or one of the three other major subtypes of ovarian cancer (mutation in PIK3CA, PTEN, KRAS, BRAF, CTNNB1 or ARID1A; mutation or amplification in ERBB2). The colour gradient underlying the cell line names to the left indicates better (green) versus poorer (red) models of HGSOC according to selected characteristics (TP53 status, correlation with mean CNA profile of TCGA samples, low mutation rate and absence of mutations in the seven ‘non-HGSOC’ genes, see Supplementary Data S1). The hypermutated cell lines described in Fig. 2 are located at the bottom of the table. Note that although HGSOC cell lines are probably at the top and unsuitable cell lines are at the bottom of the table (vertical labels), the order does not signify an exact ranking of cell line models.

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