Figure 2: Hypermutated cell lines are outliers. | Nature Communications

Figure 2: Hypermutated cell lines are outliers.

From: Evaluating cell lines as tumour models by comparison of genomic profiles

Figure 2

The comparison of mutation frequency (horizontal) and degree of CNA (vertical) for HGSOC tumour samples (blue) and ovarian cancer cell lines (red) reveals a subset of cell lines (dashed ellipse) with a hypermutator genotype (high mutation frequency, few DNA copy-number changes). The hypermutated cell lines (mutation frequency in parentheses) are: IGROV1 (20.7/Mb), OC316 (19.0/Mb), EFO27 (16.1/Mb), OVK18 (14.4/Mb) and TOV21G (13.4/Mb). Cell lines that on the contrary resemble the tumour samples in key characteristics (as shown below in Fig. 3) are also labelled.

Back to article page