Table 3 Determinants of tissue TL (univariate and multivariate analysis).

From: Telomeres shorten at equivalent rates in somatic tissues of adults

  Univariate Multivariate
  R2 (%) P R2 (%) P
Leucocyte TL
 Age 17.5 0.0002 17.5 0.0002
 Sex 3.6 0.08 0.13
 BMI 0.6 0.50 0.58
 Race/ethnicity 4.8 0.042 0.14
 Model    17.5  
Muscle TL
 Age 11.7 0.001 8.2 0.004
 Sex 7.9 0.008 4.8 0.027
 BMI 0.9 0.39 0.12
 Race/ethnicity 8.2 0.007 3.8 0.047
 Model    22.0  
Skin TL
 Age 12.5 0.0008 10.5 0.002
 Sex 1.0 0.35 0.36
 BMI 4.6 0.049 3.9 0.055
 Race/ethnicity 0.1 0.76 0.95
 Model    15.0  
Fat TL
 Age 13.3 0.0005 12.4 0.001
 Sex 0.3 0.62 0.67
 BMI 5.7 0.03 4.9 0.03
 Race/ethnicity 0.5 0.51 0.58
 Model    18.1  
  1. BMI, body mass index; TL, telomere length.
  2. The associations of age, sex, BMI (continuous variables) and race/ethnicity (Blacks versus others) with TL were tested in univariate and multivariate models. R2 represents the contribution (%) of each of the variables to TL. Only R2 values of variables that were significantly associated with leukocyte TL in the multivariate analysis are shown. R2 of the model represents the joint contribution to TL of the tested variables in the multivariate analysis.