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Controlling colloidal phase transitions with critical Casimir forces

Abstract

The critical Casimir force provides a thermodynamic analogue of the quantum mechanical Casimir force that arises from the confinement of electromagnetic field fluctuations. In its thermodynamic analogue, two surfaces immersed in a critical solvent mixture attract each other due to confinement of solvent concentration fluctuations. Here, we demonstrate the active assembly control of colloidal equilibrium phases using critical Casimir forces. We guide colloidal particles into analogues of molecular liquid and solid phases via exquisite control over their interactions. By measuring the critical Casimir pair potential directly from density fluctuations in the colloidal gas, we obtain insight into liquefaction at small scales. We apply the van der Waals model of molecular liquefaction and show that the colloidal gas–liquid condensation is accurately described by the van der Waals theory, even on the scale of a few particles. These results open up new possibilities in the active assembly control of micro and nanostructures.

Introduction

The critical Casimir effect provides an interesting analogue of the quantum mechanical Casimir effect1,2,3,4. Close to the critical point of a binary liquid, concentration fluctuations become long range, and the confinement of these long-range fluctuations gives rise to critical Casimir interactions. This offers excellent new opportunities to achieve active control over the assembly of colloidal particles5,6,7,8,9,10. At close distance, solvent fluctuations confined between the particle surfaces lead to an effective attraction that adjusts with temperature on a molecular timescale. Because the solvent correlation length depends on temperature, temperature provides a unique control parameter to control the range and strength of this interaction3. The advantage of this effect is its universality: as other critical phenomena, the scaling functions depend only on the symmetries of the system and are independent of material properties, allowing similar interaction control for a wide range of colloidal particles9. Such interaction control offers fascinating new opportunities for the design of structures at the micrometre and nanometre scale with reversible control.

Here, we demonstrate the direct control of equilibrium phase transitions with critical Casimir forces. Through exquisite control of the particle pair potential with temperature, we assemble colloidal particles into analogues of molecular liquid and solid phases, and we visualize these phases in three dimensions and on the single-particle level. Because of the similarity of the critical Casimir and molecular potentials, these observations allow insight into molecular liquefaction at small scales. In 1873, van der Waals11 presented a universal model for the condensation of gases: gas–liquid condensation reflects the competition between the energy cost for compression of the particles against their entropic pressure, and the energy gain from the condensation of the attractive particles. van der Waals obtained a universal equation for the condensation of gases by accounting for the average molecular attraction and the finite molecule volume. While for molecular gases, experimental confirmation of this relation remained indirect, our colloidal system allows direct microscopic observation and measurement of the liquid condensation. We measure important parameters of the condensation process: the particle pair potential, the equilibrium densities of liquid and gas phases and the relative amount of gas and liquid. These microscopic observations allow us to test the van der Waals model at small scales. We find that the model describes the particle condensation in our colloidal system remarkably well, even on the scale of a few particles, indicating that this relatively simple mean-field model may also apply to describe the condensation of nanoparticles in the formation of nanostructures.

Results

Observation of colloidal phase transitions

We induce critical Casimir interactions by approaching the phase-separation temperature, Tc, of the binary solvent; we tune these interactions continuously in a temperature range of ΔT=0.5–0.2 °C below Tc. By using a new optically and density-matched colloidal system (see Methods), we can directly follow individual particles deep in the bulk of the system. The convenient temperature control allows us to induce remarkable transitions in the colloidal system. Sufficiently far below Tc, the particles are uniformly suspended and form a dilute gas phase (Fig. 1a). However, at ΔT=0.3 °C the particles condense and form spherical aggregates that coexist with a low-density colloidal gas (Fig. 1b). We observe that within the aggregates, particles exhibit the diffusive motion characteristic of liquids (Supplementary Movie 1). This is confirmed by tracking the motion of the particles, and comparing their mean-square displacement with that of the particles in the dilute gas (Fig. 1c). The mean-square displacement grows linearly in time, similar to that of the molecular motion in liquids. Moreover, it grows slower than that of the gas particles, indicating the confinement of the particles in the dense liquid environment. We conclude that the particles form a condensed phase analogous to that of molecular liquids. When we raise the temperature further to ΔT=0.2 °C, the particles inside the aggregates form an ordered face-centered cubic lattice (Fig. 1d): the colloidal liquid has frozen into a crystal. These observations provide direct analogues of gas–liquid and liquid–solid transitions, driven by critical Casimir interactions. Because of the exquisite temperature dependence of these interactions, the phase transitions are reversible: the crystals melt, and the liquid drops evaporate when the temperature is lowered below the characteristic thresholds (Supplementary Movie 2). Such reversible control offers new opportunities to guide the growth of perfect structures from colloidal building blocks12. The exquisite temperature dependence and reversibility allows precise control over the growth and annealing of perfect equilibrium structures, in analogy to the growth of atomic materials.

Figure 1: Colloidal phase transitions induced by critical Casimir forces.
figure1

(a,b,d) Confocal microscope images of colloidal gas–liquid–solid transitions: colloidal gas (a), colloidal liquid aggregates (b) and colloidal crystal (d). Scale bar, 1 μm (a). Inset in d illustrates the relation between the imaged particle configuration and the structural motif of the face-centered cubic lattice. (c) Mean-square displacement of particles in the liquid (circles) and gas (dots). Linear fits to the data yield diffusion coefficients that differ by a factor of 10. (e,f) Three-dimensional reconstructions of gas and liquid correspond to the confocal images (a,b). Red and blue spheres indicate particles with a large and small number of nearest neighbours, respectively. Red particles in e demarcate density fluctuations of the colloidal gas, whereas red particles in f indicate the nucleated colloidal liquid phase coexisting with the colloidal gas.

To elucidate the gas–liquid condensation in more detail, we show three-dimensional reconstructions in Fig. 1e, where we distinguish gas and liquid particles by the number of their respective nearest neighbours13; red spheres indicate particles with five and more neighbours, and small blue spheres indicate particles with less than five neighbours. Interestingly, at ΔT=0.5 °C, small clusters of red particles appear and disappear, indicating spontaneous fluctuations in the density of the colloidal gas (Fig. 1e). These density fluctuations become more pronounced as the temperature approaches Tc (Supplementary Movie 1). At ΔT=0.3 °C, after 10 min, red spheres form stable liquid nuclei (Fig. 1f) that grow to become large drops. After 30 min, we measure the density of particles in the liquid and gas phases from the number of red and blue particles per volume, and obtain ρliq=3.2 μm−3 and ρgas=0.05 μm−3, respectively.

Direct measurement of critical Casimir pair potential

We elucidate the mechanism that drives the condensation of particles by measuring the particle pair potential directly from the density fluctuations in the gas. The potential of mean force, Umf, is related directly to the pair correlation function, g(r) that indicates the probability of finding two particles separated by r, via g(r)exp[−Umf(r)/kBT] (refs 14, 15). For dilute suspensions, UmfU, and the pair potential is obtained directly from the measurement of g(r). We acquire 3,000 images of particle configurations of the colloidal gas to determine the average pair correlation function at different temperatures, which we show in Fig. 2a, inset. An increasing peak arises at r2.7r0 as the temperature approaches Tc, indicating increasing particle attraction. The resulting pair potentials U(r)/kBT=−ln g(r), shown in Fig. 2a, demonstrate an increasing attractive minimum as the temperature approaches Tc. This minimum reflects the competition between the critical Casimir attraction, and the screened electrostatic repulsion of the particles. We consider the total pair potential U=Urep+Uattr, where is the screened electrostatic potential associated with the charged particles16 and Uattr is the attractive critical Casimir potential, which we approximate by (ref. 7). Here, Aattr2πr0kBT/lattr is the amplitude and lattr the range of the critical Casimir attraction, and l=r−2r0 is the distance between particle surfaces. We determine the electrostatic repulsion from the measurement at room temperature, where critical Casimir interactions are negligible. Excellent agreement with the data is obtained for Arep=4.3kBT and lrep=0.36r0 (black circles and solid line in Fig. 2a). The attractive critical Casimir potential is then determined from the best fit of U to the measured potentials; the resulting critical Casimir potential is shown in Fig. 2b, and the values of Aattr and lattr are shown in the inset. The data indicate that lattr grows linearly with temperature, while the amplitude Aattr1/lattr, as expected for the critical Casimir force between two spheres7. The range of the attractive potential at ΔT=0.3 K is lattr=80 nm, of the order of, but a factor of 2 larger than the solvent correlation length ξ=40 nm determined from independent dynamic light-scattering measurements. We associate this difference with the fluffiness of the poly-n-isopropyl acrylamide (PNIPAM) particles: dangling polymer arms sticking out of the PNIPAM particle surface can decrease the effective surface-to-surface distance between particles, thereby increasing the effective range of their interaction. We note that measurements of the bare correlation length of the 3-methyl pyridine (3-MP)–water mixture are reported in 17.

Figure 2: Measurement of the particle pair potential.
figure2

(a) Temperature-dependent particle pair potential determined from the pair correlation function shown in the inset. The symbols indicate room temperature (black circles), ΔT=0.5 °C (red squares), 0.4 °C (green rhombi), 0.35 °C (blue hexagons) and 0.30 °C (magenta stars). The solid black line indicates the best fit with a screened electrostatic potential. (b) Attractive critical Casimir potentials extracted from the potential curves in a. Inset: range lattr (black-filled square) and amplitude Aattr (red open circle) of the critical Casimir potential as a function of ΔT. Dashed lines are guides to the eye.

Discussion

The precision of these measurements allows us to make direct comparison with continuum models. The widely used van der Waals equation of state provides a universal model for molecular gas–liquid condensation. To describe attractive molecules of finite size, van der Waals modified the ideal gas equation of state PV=NkBT that relates the pressure P, the volume V, the number of molecules N and the temperature T, to (ref. 11). The finite molecule size reduces the volume accessible to the molecules by Nb, where b indicates the volume around a single particle from which all other particles are excluded. The attraction between molecules reduces the pressure by N2a/V2, where a accounts for the attractive potential of a particle due to the existence of all other particles. While for molecular gases, values of a and b can only be inferred from macroscopic measurements, for our colloidal system, we can determine the parameters a and b directly from the measured particle pair potential and particle size using and b≈0.5Vexcl (ref. 16), where the excluded volume Vexcl=(4/3)π(2r0)3. These relations can be strictly derived for particles interacting with a hard-core repulsion, followed by an attractive potential part for r>r1, by summing the interactions over all particle pairs. Furthermore, while for molecular gases, the value of a is temperature independent, and the only change with temperature occurs in the thermal energy, kBT, for our colloidal system, temperature changes directly the value of a via the critical Casimir interactions. We determine values of a by numerical integration of the measured pair potentials (Table 1), and b from the measured particle radius, and plot the resultant P as a function of V/Nb in Fig. 3. The values of a result in four isotherms. Red and green curves show isotherms characteristic of a gas, whereas blue and pink curves show non-monotonic functions indicating gas–liquid condensation. To pinpoint the equilibrium gas–liquid coexistence, we construct horizontal tie lines that include equal areas with the isotherms18,19; these tie lines intersect the isotherms at vliq and vgas, the specific volumes of equilibrium liquid and gas phases that bound the coexistence regime. The model predicts that systems with average specific volume within the coexistence regime separate into phases with relative fraction and . To test this prediction, we determine the average volume per particle using , and indicate the resulting value with a vertical dashed line. This value falls within the coexistence regime of only the pink isotherm, indicating that gas–liquid coexistence should occur only for ΔT=0.30 °C, in agreement with our experimental observation (Fig. 1). Further confirmation of the model comes from comparison of the measured and predicted values of vliq and vgas. We determine the specific volumes of gas and liquid particles from the measured volume fractions φliq=0.25 and φgas=0.005 and obtain vliq/b=1 and vgas/b=50, in good agreement with the predicted values vliq/b=1.25±0.31 and vgas/b=43±25 determined from Fig. 3. Here, the error margin of the van der Waals isotherms has been estimated from the error margin of the values of a and b due to the inaccuracy of the measured particle size, and the measured pair potential. Furthermore, the relative amount of liquid and gas is fliq=0.69 and fgas=0.31, again in good agreement with the values fliq=0.72±0.1 and fgas=0.28±0.1 determined from Fig. 3. These results indicate that the van der Waals model provides a quantitatively accurate description of the colloidal gas–liquid equilibrium. We note that explicit measurement of the surface and bulk free energies20 indicates that the critical radius of nucleation is 2–3 times smaller than the radius of the droplets analysed here; this suggests that indeed the bulk free energy term starts to dominate the surface term, and the van der Waals theory for bulk gas–liquid coexistence might apply.

Table 1 Temperature-dependent van der Waals coefficient.
Figure 3: van der Waals isotherms of the colloidal gas–liquid transition.
figure3

van der Waals isotherms determined from the particle pair potential at ΔT=0.5 °C (red), 0.4 °C (green), 0.35 °C (blue) and 0.3 °C (pink). A transition from a gas (green and red isotherms) to gas–liquid coexistence (blue and pink isotherms) is predicted. Horizontal tie lines are constructed according to the Maxwell rule of equal chemical potential, including equal areas with isotherms. Intersections with the isotherms delineate the gas–liquid coexistence regimes. Vertical dashed line indicates the average volume per particle, . Inset: enlarged section of the particle pair potential at ΔT=0.35 °C illustrates the determination of the van der Waals parameter a by integration. The lower integration boundary, r1, is indicated by a dotted line.

The strength of the van der Waals model is its universality, as reflected in the principle of corresponding states. A wide range of molecular gases show the same behaviour when the parameters pressure, temperature and density are scaled by their values at the critical point. We can test for this principle by comparing the normalized gas and liquid densities in our colloidal system with the well-known universal behaviour of molecular gases. To do so, we determine the critical temperature Tc=(8a/27bR) and critical density ρc=N/3b using the van der Waals parameters a and b, and the universal gas constant R. We plot the rescaled temperature T/Tc as a function of the rescaled gas–liquid density difference in Fig. 4 inset. Here, we have taken T325 K, the temperature of the experiment. Circles denote the gas–liquid equilibrium described above, and squares indicate gas–liquid equilibria obtained for a binary solvent with composition slightly closer to the critical composition. The solid line indicates the universal behaviour of a wide range of molecular gases18. This line provides a very good fit to the colloidal data without any adjustable parameters, indicating that this universal description applies to the colloidal system as well. We can further test the correspondence between our colloidal and molecular systems by using the law of rectilinear diameters for the average density21,22 to determine the gas and liquid phase boundaries. We compare the rescaled temperature as a function of rescaled density of the colloid (symbols) with the universal behaviour of molecular gases (solid lines) in the main panel of Fig. 4. Excellent agreement is observed, suggesting close correspondence between the colloidal system and molecular gases; this indicates that indeed the principle of corresponding states applies to the colloidal systems as well. We note that, however, more data close to the gas–liquid critical point are needed to strictly verify the corresponding critical scaling in the colloidal system.

Figure 4: Colloidal gas–liquid phase diagram and comparison with molecular gases.
figure4

Normalized temperature as a function of normalized gas and liquid densities for the colloidal system (symbols) and for molecular gases (solid line). Open symbols indicate gas and liquid densities measured by microscopy, and closed symbols indicate the values obtained from the van der Waals isotherms as shown in Fig. 3. Error bars indicate the error in the density determined by confocal microscopy, and in the predicted gas and liquid densities as described in the text. The graph compiles data for two different binary solvents with 25% 3MP (circles) and 28% 3MP (squares); the latter extends the range of the colloidal interaction. The solid line indicates the universal behaviour of a wide range of molecular gases according to the equation [(ρliqρgas)/ρc]=(7/2)[1−(T/Tc)](1/3) (ref. 18), and the law of rectilinear diameters21,22. It provides an excellent fit to the colloidal data. Inset: normalized density difference of liquid and gas as a function of normalized temperature difference to the critical temperature. The solid line indicates the universal equation for molecular gases.

Molecular gas–liquid condensation typically entails measurement of the equilibrium vapour pressure, Peq(T). For our colloidal system, this pressure is small and difficult to measure. However, we can estimate Peq from the intersection of the horizontal tie line with the y axis. From Fig. 3, we find Peq=0.025(kBT/b) yielding an equilibrium vapour pressure of 2·10−4 Pa, 109 times smaller than typical vapour pressures of molecular gases at room temperature, which are of the order of 105 Pa, the atmospheric pressure. This difference reflects the 109 times lower colloidal particle density associated with the 103 times larger colloidal particle diameter. Therefore, the gas–liquid transitions in the colloidal and molecular systems are comparable.

The active and reversible control of colloidal gas–liquid and liquid–solid transitions lays the groundwork for novel assembly techniques, making use of critical Casimir forces by a unique procedure of precise temperature control. Because of the reversibility of the interactions, temperature gradient and zone-melting techniques can be applied to grow perfect equilibrium structures, in analogy to atomic crystal growth. Furthermore, the correspondence of the colloidal and the molecular gas–liquid transition opens new opportunities to further investigate equilibrium and non-equilibrium phenomena using active potential control. For example, quenches to temperatures even closer to the critical point induce fractal aggregates23 and gelation of the particles. The temperature dependence in this case offers convenient control to tune the morphology of the assembled structures. Finally, the close agreement between the molecular van der Waals theory and the colloidal phase separation that we observe on the scale of just a few particle diameters is surprising, and suggests that such mean-field theories may also be applied to describe the condensation of nanoparticles in the assembly of nanostructures. We foresee that more complex structures can be obtained by patterning the particle surfaces to create anisotropic critical Casimir interactions. Such surface modification might allow mimicking ‘atomic orbitals’ to assemble colloidal particles into structures similarly complex as those of molecules.

Methods

Binary solvent

We use a quasi two-component solvent consisting of 3MP, water and heavy water6,24 with mass fractions of 0.25, 0.375 and 0.375, respectively. This composition is close to, but slightly lower than the critical composition with 3MP mass fraction 0.31 (ref. 25), resulting in a slightly extended temperature interval of aggregation. This solvent mixture separates into 3MP-rich and water-rich components upon heating to Tc=52.2 °C, the solvent phase-separation temperature. This solvent was used for all results presented in this manuscript. In addition, in Fig. 4, we also include data from a binary solvent with 3MP mass fraction 0.28, to demonstrate a more diverse collection of data.

Colloidal particles

To follow the aggregation due to critical Casimir forces deep in the bulk of the suspension, we use particles whose refractive index and density match closely with that of the solvent. Similar observations obtained with other particle materials show that the results presented here are general, and do not depend on the specific particle material used. We use PNIPAM particles26,27 that swell in the binary solvent. The swelling adjusts the particle refractive index and density to match closely with that of the solvent in the swollen state, preventing particle sedimentation, and allowing direct observation of individual particles deep in the bulk. The particle size changes only weakly with temperature, and is constant in the temperature interval of interest here. At TTc, the particle radius is r0250 nm, and the particle volume fraction is 2%. The particles are labelled with a fluorescent dye that makes them visible under fluorescent imaging.

Observation of colloidal phase transitions

We tune critical Casimir interactions continuously by varying the solvent correlation length with temperature in a range of ΔT=0.5–0.2 °C below Tc. We then follow colloidal phase transitions directly in real space and time by imaging individual particles in a 65 μm × 65 μm × 25 μm volume with confocal microscopy, and determining their positions with an accuracy of 0.03 μm in the horizontal, and 0.05 μm in the vertical direction28.

Additional information

How to cite this article: Nguyen, V.D. et al. Controlling colloidal phase transitions with critical Casimir forces. Nat. Commun. 4:1584 doi: 10.1038/ncomms2597 (2013).

References

  1. 1

    Fukuto, M., Yano, Y. F. & Pershan, P. S. . Critical Casimir effect in three-dimensional Ising systems: measurements on binary wetting films. Phys. Rev. Lett. 94, 135702 (2005).

    ADS  Article  Google Scholar 

  2. 2

    Rafai, S., Bonn, D. & Meunier, J. . Repulsive and attractive critical Casimir forces. Physica A 386, 31–35 (2007).

    ADS  Article  Google Scholar 

  3. 3

    Hertlein, C., Helden, L., Gambassi, A., Dietrich, S. & Bechinger, C. . Direct measurement of critical Casimir forces. Nature 451, 172–175 (2008).

    CAS  ADS  Article  Google Scholar 

  4. 4

    Fisher, M. E. & de Gennes, P. -G. . Physique des colloides. C. R. Acad. Sci. Ser. B 287, 207–209 (1978).

    CAS  Google Scholar 

  5. 5

    Beysens, D. & Esteve, D. . Adsorption phenomena at the surface of silica spheres in a binary liquid mixture. Phys. Rev. Lett. 54, 2123–2126 (1985).

    CAS  ADS  Article  Google Scholar 

  6. 6

    Beysens, D. & Narayanan, T. . Wetting-induced aggregation of colloids. J. Stat. Phys. 95, 997–1008 (1999).

    ADS  Article  Google Scholar 

  7. 7

    Bonn, D. et al. Direct observation of colloidal aggregation by critical Casimir forces. Phys. Rev. Lett. 103, 156101 (2009).

    ADS  Article  Google Scholar 

  8. 8

    Guo, H., Narayanan, T., Sztuchi, M., Schall, P. & Wegdam, G. H. . Reversible phase transition of colloids in a binary liquid solvent. Phys. Rev. Lett. 100, 188303 (2008).

    ADS  Article  Google Scholar 

  9. 9

    Gambassi, A. et al. Critical Casimir effect in classical binary liquid mixtures. Phys. Rev. E 80, 061143 (2009).

    CAS  ADS  Article  Google Scholar 

  10. 10

    Mohry, T. F., Maciołek, A. & Dietrich, S. . Phase behavior of colloidal suspensions with critical solvents in terms of effective interactions. J. Chem. Phys. 136, 224902 (2012).

    CAS  ADS  Article  Google Scholar 

  11. 11

    van der Waals, J. D. . Dissertation. Over de Continuiteit van den Gas- en Vloeistoftoestand (Univ. Leiden (1873).

  12. 12

    Glotzer, S. C. & Solomon, M. J. . Anisotropy of building blocks and their assembly into complex structures. Nat. Mater. 6, 557–562 (2007).

    Article  Google Scholar 

  13. 13

    ten Wolde, P. R. & Frenkel, D. . Computer simulation study of gas–liquid nucleation in a Lennard-Jones system. J. Chem. Phys. 109, 9901–9918 (1998).

    CAS  ADS  Article  Google Scholar 

  14. 14

    Behrens, S. H. & Grier, D. G. . Pair interaction of charged colloidal spheres near a charged wall. Phys. Rev. E 64, 050401 (2001).

    CAS  ADS  Article  Google Scholar 

  15. 15

    Royall, C. P., Louis, A. A. & Tanaka, H. . Measuring colloidal interactions with confocal microscopy. J. Chem. Phys. 127, 044507 (2007).

    ADS  Article  Google Scholar 

  16. 16

    Israelachvili, J. . Intermolecular & Surface Forces Academic Press (1992).

  17. 17

    Narayanan, T. & Kumar, A. . Reentrant phase transitions in multicomponent liquid mixtures. Phys. Rep. 249, 135–218 (1994).

    CAS  ADS  Article  Google Scholar 

  18. 18

    Huang, K. . Introduction to Statistical Physics CRC Press (2010).

  19. 19

    Maxwell, J. C. . The Scientific Papers of James Clerk Maxwell Dover Publ. Inc. (1952).

  20. 20

    Nguyen, V. D. . Phase transitions and interfaces in temperature-sensitive colloidal systems PhD thesis, Univ. Amsterdam (2012) (ISBN 978-90-6464-910-2).

  21. 21

    Cailletet, L. & Mathias, E. C. . Séanc . Acad. Sci. Compt. Rend. Hebd., Paris 102, 1202 (1886); 104, 1563 (1887).

  22. 22

    Rowlinson, J. S. & Swinton, F. L. . Liquids and Liquid Mixtures. 3rd edn. Butterworth (1982).

  23. 23

    Veen, S. J. et al. Colloidal aggregation in microgravity by critical Casimir forces. Phys. Rev. Lett. 109, 248302 (2012).

    ADS  Article  Google Scholar 

  24. 24

    Narayanan, T., Kumar, A. & Gopal, E. S. R. . A new description regarding the approach to double criticality in quasi-binary liquid mixtures. Phys. Lett. A 155, 276–280 (1991).

    CAS  ADS  Article  Google Scholar 

  25. 25

    Cox, J. D. . Phase relationships in the pyridine series. Part II. The miscibility of some pyridine homologues with deuterium oxide. J. Chem. Soc. 4606–4608 (1952).

  26. 26

    Pelton, R. H. . Temperature-sensitive aqueous microgels. Adv. Colloid Interface Sci. 85, 1–33 (2000).

    CAS  ADS  Article  Google Scholar 

  27. 27

    Senff, H. & Richtering, W. . Temperature sensitive microgel suspensions: Colloidal phase behavior and rheology of soft spheres. J. Chem. Phys. 111, 1705–1711 (1999).

    CAS  ADS  Article  Google Scholar 

  28. 28

    Weeks, E. R., Crocker, J. C., Levitt, A. C., Schofield, A. B. & Weitz, D. A. . Three-dimensional direct imaging of structural relaxation near the colloidal glass transition. Science 287, 627–631 (2000).

    CAS  ADS  Article  Google Scholar 

Download references

Acknowledgements

We thank P. Bolhuis and D. Bonn for helpful discussions. This work was supported by the Innovational Research Incentives Scheme (‘VIDI’ grant) of the Netherlands Organization for Scientific Research (NWO) (P.S.).

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Authors

Contributions

V.D.N. performed the experiments and wrote the first manuscript draft. S.F. contributed to the analysis of the particle pair potential and the van der Waals model. Z.H. made the PNIPAM particles. G.H.W. contributed to discussion on the results of the manuscript. P.S. conceived the experiments and wrote the final manuscript.

Corresponding author

Correspondence to Peter Schall.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Movie1

Confocal microscope movie of the colloidal gas-liquid transition. We image the nucleation and growth of the colloidal liquid phase upon approaching the phase separation temperature, Tc, of the solvent. The slowly increasing temperature leads to increasing critical Casimir attractions between the particles. In this particular movie, we start at ΔT = 0.4°C below Tc, and we raise the temperature continuously to ΔT = 0.25K. The movie shows numerous nucleation and growth events. The total time interval is 60 minutes. (AVI 7542 kb)

Supplementary Movie2

Confocal microscope movie of the evaporation of the colloidal liquid. We image the evaporation of colloidal liquid drops during slow cooling, which reduces the critical Casimir interactions between the particles. In this movie, we start at ?T = 0.25°C below the solvent phase separation temperature, at which a colloidal gas-liquid equilibrium has developed, and we lower the temperature to ΔT = 0.5°C to reduce the critical Casimir interactions. The movie shows the evaporation of the colloidal liquid droplets. These observations demonstrate the reversibility of the condensation process offering new reversible control of micro and nanoparticle assembly. (AVI 5879 kb)

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Nguyen, V., Faber, S., Hu, Z. et al. Controlling colloidal phase transitions with critical Casimir forces. Nat Commun 4, 1584 (2013). https://doi.org/10.1038/ncomms2597

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