Figure 7 : Long-term prevention of photoreceptor degeneration after Sema4A gene transfer.

From: A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration

Figure 7

Similar to Figure 6, gene transfer with the lentiviral vectors expressing Sema4AWT-FLAG was performed in 1-week-old Sema4AF350C/F350C mice. Subsequently, we evaluated the retinal histology of these mice at 1, 2 or 4 months of age to estimate the duration of the therapeutic effects. As shown in the representative images, photoreceptor cells were preserved at least 4 months after gene transfer. Scale bar, 50 μm.