Figure 4 : MDCS selection of RNA motifs that bind to small molecules.

From: Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations

Figure 4

(a) Image of a microarray displaying the eight hit compounds after hybridization with radioactively labeled 13 and unlabeled 48 (Fig. 2)20,21,48, and a plot of the corresponding data. Only PL-1, HL-1, HL-2 and DL-1 bind to 13 under these highly stringent conditions and were subjected to microarray-based selections. (b) Image of a microarray displaying PL-1, HL-1, HL-2 and DL-1 after hybridization with radioactively labeled 13 and unlabeled competitors 48, and a plot of the corresponding data. The error bars are the standard deviations.