Figure 1: Strategies to construct multivalent assemblies. | Nature Communications

Figure 1: Strategies to construct multivalent assemblies.

From: Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds

Figure 1

(a) Step-by-step syntheses afford an accurate valency but are limited to low numbers of ligands. (b) Shotgun methods provide high valencies but an error (ɛ) is associated with the number of ligands. (c) Scaffolds made using LKγ-PNA and nucleic acid (NA) allow access to multivalent assemblies with both high valencies and accurate ligand number. Valency of an LKγ-PNA-NA assembly is the product of the number of complementary binding sites incorporated into the NA (x) and the number of ligands displayed from each PNA oligomer (y).

Back to article page