Figure 6: Biophysical analyses for the binding of lead compounds to c-MYC. | Nature Communications

Figure 6: Biophysical analyses for the binding of lead compounds to c-MYC.

From: Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor

Figure 6

(ac) FRET melting profiles of 100 nM c-MYC G-quadruplex (Tm=70.9±1.2 °C) and dsDNA (Tm=61.3±2.1 °C) with increasing amounts of triazole products Tz 1, 2 and 3 (0–10 μM) in 60 mM potassium cacodylate buffer, pH=7.4. (di) Fluorescence responses of Tz 13 (1 μM) upon titration with c-MYC G-quadruplex DNA and duplex DNA.

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