Figure 2 : Feasibility of strong coupling in Escherichia coli and Saccharomyces cerevisiae.

From: Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms

Figure 2

Percentage of substrate-producible organic metabolites from E. coli and S. cerevisiae for which feasibility (coloured bars) or infeasibility (grey bars) of strong coupling can be proven, depending on the minimum yield level and conditions used. Statistics for the cut set sizes and MILP computation time are given in the table. The column (50*) for E. coli (aerobic growth) shows the cMCS sizes that result when the solver is restarted from the solution associated with the original cut set (for 50% minimum yield level) and minimization of the number of cuts is continued for up to 10 min for each cMCS. Sixty-eight of the cMCS found in this way can even be proven to be the smallest cMCS, that is, the solver has found an optimal solution.