Figure 1 : Design of production strains with growth-coupled product synthesis.

From: Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms

Figure 1

The yield space shows the projection of all feasible steady-state flux distributions in the network with respect to their biomass yield and product yield. Herein we demand strong coupling, meaning that in the mutant strain to be constructed, growth without product synthesis is not possible anymore (production without growth is allowed). All (remaining) flux distributions in the mutant strain reach a product yield above a demanded threshold.